Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany.
Eur Arch Psychiatry Clin Neurosci. 2011 Apr;261(3):213-6. doi: 10.1007/s00406-010-0150-x. Epub 2010 Sep 26.
Studies using diffusion tensor imaging (DTI) have shown multifocal reduction in anisotropy of white matter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P < 0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P < 0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not support ADC changes to be a marker of white matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder.
使用弥散张量成像（DTI）的研究表明精神分裂症患者的白质纤维束各向异性多灶性减少，其中一些研究还提示表观扩散系数（ADC）的变化。在这项研究中，我们使用基于体素的方法评估了 18 名精神分裂症患者和 18 名健康对照者的 ADC。我们没有发现使用不同平滑滤波器大小的 ADC 在任何方向上有统计学意义的变化（FDR 校正）；只有在未校正的 P < 0.001 阈值下，我们才发现靠近我们之前发现的 FA 的右侧前额叶小区域的 ADC 增加。因此，我们的研究结果不支持 ADC 变化作为精神分裂症白质或灰质异常的标志物。其他参数如分数各向异性（FA）的变化可能是这种疾病白质病理的更敏感指标。
