Tan Zheng, Shang Xiaoming, Li Li, Tian Luobing, Ma Yi, Peng Yan, Gao Lingxi
Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017;
Exp Ther Med. 2013 Apr;5(4):1133-1136. doi: 10.3892/etm.2013.958. Epub 2013 Feb 18.
The aim of this study was to observe and investigate the clinical efficacy of an intravenous drip of isosorbide mononitrate (ISMN) for the treatment of angina pectoris in coronary heart disease. A total of 102 patients with angina pectoris in coronary heart disease were divided into two groups. For the treatment group (n=51), 20 mg ISMN was added to 250 ml 0.9% normal saline and administered by intravenous drip for 14 consecutive days, twice daily. For the control group (n=51), 10 mg glyceryl trinitrate was added to 250 ml 0.9% normal saline and administered by intravenous drip for 14 consecutive days, twice daily. The clinical efficacy and adverse reactions were compared between the two groups. The disease symptoms of the two groups were improved. Compared with the control group, the clinical efficacy and electrocardiogram examination results of the treatment group were significantly improved (P<0.05). The intravenous formulation of ISMN is an effective treatment for angina pectoris in coronary heart disease and it has the advantages of fewer adverse reactions and higher safety.
本研究旨在观察和探讨静脉滴注单硝酸异山梨酯(ISMN)治疗冠心病心绞痛的临床疗效。将102例冠心病心绞痛患者分为两组。治疗组(n = 51),将20 mg ISMN加入250 ml 0.9%生理盐水中,静脉滴注,连续14天,每日2次。对照组(n = 51),将10 mg硝酸甘油加入250 ml 0.9%生理盐水中,静脉滴注,连续14天,每日2次。比较两组的临床疗效和不良反应。两组的疾病症状均有改善。与对照组相比,治疗组的临床疗效和心电图检查结果明显改善(P<0.05)。ISMN静脉制剂是治疗冠心病心绞痛的有效方法,具有不良反应少、安全性高的优点。