Department of Urology, Chonbuk National University Medical School, Jeonju, Korea. ; Institute for Medical Sciences, Chonbuk National University, Jeonju, Korea. ; Biomedical Research Institute and Clinical Trial Center of Medical Device, Chonbuk National University Hospital, Jeonju, Korea.
World J Mens Health. 2012 Dec;30(3):177-82. doi: 10.5534/wjmh.2012.30.3.177. Epub 2012 Dec 27.
The purpose of this study is to evaluate the preoperative factors that influenced postoperative sperm concentration after vasovasostomy.
We retrospectively reviewed 97 consecutive single-layer vasovasostomy procedures performed by a single surgeon between March 2003 and September 2010. The patients were stratified into three groups based on sperm concentration at 1 month follow-up: group I-azoospermia, group II-oligospermia, and group III-normal. We evaluated the preoperative factors that may have influenced sperm concentration at postoperative 1 month. Patients with serial semen analysis were divided into four groups according to the change in postoperative sperm concentration at the 6-month visit: group II-N-from oligospermia to normal, group II-O-from oligospermia to oligospermia, group III-O-from normal to oligospermia, group III-N-from normal to normal. We compared the pregnancy rate among the four groups.
The mean obstructive interval was 9.69 years in group I, 6.02 years in group II, and 7.82 years in group III. There were significant differences found among the groups (p=0.035). There was significantly different change in sperm concentration, sperm motility, and sperm morphology between each of the groups. A total of 32 patients underwent serial semen analyses at 1 month, 3 months, and 6 months after vasovasostomy. There was no significant difference in patient age, obstructive interval, or follicle-stimulating hormone among the groups. The natural pregnancy rate in group II-O was lower than that in group II-N, and in group III-O was lower than that in group III-N. However, there was no significant difference among each of the groups.
The sperm concentration after vasovasostomy was significantly related to the obstructive interval between vasectomy and reversal.
本研究旨在评估影响吻合术后精子浓度的术前因素。
我们回顾性分析了 2003 年 3 月至 2010 年 9 月期间由一位外科医生进行的 97 例单层层吻合术。根据术后 1 个月的精子浓度将患者分为三组：I 组-无精子症，II 组-少精子症，III 组-正常。我们评估了可能影响术后 1 个月精子浓度的术前因素。对接受连续精液分析的患者，根据术后 6 个月精子浓度的变化分为四组：II-N 组-从少精子症到正常，II-O 组-从少精子症到少精子症，III-O 组-从正常到少精子症，III-N 组-从正常到正常。我们比较了四组之间的妊娠率。
I 组的平均梗阻时间为 9.69 年，II 组为 6.02 年，III 组为 7.82 年。各组之间存在显著差异（p=0.035）。各组间精子浓度、精子活力和精子形态均有显著差异。共有 32 例患者在吻合术后 1 个月、3 个月和 6 个月进行了连续精液分析。各组间患者年龄、梗阻时间或促卵泡激素均无显著差异。II-O 组的自然妊娠率低于 II-N 组，III-O 组的自然妊娠率低于 III-N 组，但各组间无显著差异。
吻合术后的精子浓度与输精管结扎和再通之间的梗阻时间显著相关。
