1 Department of Mechanical Engineering, University of Alberta , Edmonton, Alberta, T6G 2G8, Canada .
J Aerosol Med Pulm Drug Deliv. 2013 Dec;26(6):317-35. doi: 10.1089/jamp.2012.1001. Epub 2013 Apr 18.
This review article discusses the development of respiratory therapeutics containing bacteriophages indicated for lung infections, specifically those that have become increasingly difficult to treat because of antibiotic resistance. Recent achievements and remaining problems are presented for each step necessary to develop a bacteriophage-containing dosage form for respiratory drug delivery, including selection of appropriate bacteriophages for therapy, processing and purification of phage preparations, formulation into a stable, solid dosage form, and delivery device selection. Safety and efficacy studies in animals and human subjects are also reviewed.
这篇综述文章讨论了含有噬菌体的呼吸治疗药物的发展，这些药物针对的是肺部感染，特别是由于抗生素耐药性而变得越来越难以治疗的感染。本文介绍了为开发用于呼吸药物递送的含噬菌体剂型而必需的每一步骤的最新成果和遗留问题，包括用于治疗的合适噬菌体的选择、噬菌体制剂的加工和纯化、制成稳定的固体剂型以及输送装置的选择。还回顾了动物和人体研究中的安全性和疗效研究。
