State University of Rio de Janeiro - Rua Farme de Amoedo 140/601, Ipanema, Rio de Janeiro 22420-020, Brazil.
Rheum Dis Clin North Am. 2013 May;39(2):401-18. doi: 10.1016/j.rdc.2013.02.009. Epub 2013 Mar 13.
SAPHO syndrome is a disorder characterized by Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. As the osteoarticular and skin manifestations often do not occur simultaneously and there are no validated diagnostic criteria, the diagnosis can be difficult. Clinical and imaging investigation is necessary to establish the many differential diagnoses of SAPHO syndrome. The etiopathogenesis involves infectious (probably Propionibacterium acnes), immunologic, and genetic factors. Treatment is based on information gathered from case reports and small series, and is related to specific skin or articular symptoms.
SAPHO 综合征是一种以滑膜炎、痤疮、脓疱病、骨肥厚和骨炎为特征的疾病。由于骨关节炎和皮肤表现通常不会同时发生，且没有经过验证的诊断标准，因此诊断可能具有一定难度。临床和影像学检查对于确定 SAPHO 综合征的众多鉴别诊断是必要的。其发病机制涉及感染（可能为痤疮丙酸杆菌）、免疫和遗传因素。治疗是基于从病例报告和小系列中收集的信息，并与特定的皮肤或关节症状有关。
