Letts M, Davidson D, Birdi N, Joseph M
Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada.
J Pediatr Orthop. 1999 May-Jun;19(3):297-300.
The SAPHO syndrome is a rare constellation of signs and symptoms characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis. The most common musculoskeletal complaints are hyperostosis, causing pain, tenderness, and swelling of the anterior chest wall, although any part of the axial and appendicular skeleton may be affected. There is a great degree of variability in the dermatologic involvement of this syndrome. A combination of clinical, radiographic, and pathological investigation is required to establish the correct diagnosis. No single treatment has been found to be effective, although nonsteroidal antiinflammatory drugs have been the most frequently used. Because there is no mention of SAPHO syndrome in the English orthopaedic literature, and pediatric orthopaedic surgeons may be the first caregivers to treat these children, we thought it appropriate to share our experience with a 5-year-old boy with SAPHO syndrome recently under our care.
滑膜炎、痤疮、脓疱病、骨质增生和骨炎综合征（SAPHO综合征）是一种罕见的体征和症状组合。最常见的肌肉骨骼症状是骨质增生，可导致前胸壁疼痛、压痛和肿胀，尽管中轴骨和四肢骨骼的任何部位都可能受累。该综合征的皮肤受累情况差异很大。需要结合临床、影像学和病理学检查来做出正确诊断。虽然非甾体类抗炎药是最常用的药物，但尚未发现单一治疗方法有效。由于英国骨科文献中未提及SAPHO综合征，而小儿骨科医生可能是治疗这些儿童的首批医护人员，我们认为分享我们最近治疗的一名患有SAPHO综合征的5岁男孩的经验是合适的。
