Fidalgo S, Vázquez F, Mendoza M C, Pérez F, Méndez F J
Microbiology Service, Hospital Covadonga, Oviedo, Spain.
Rev Infect Dis. 1990 May-Jun;12(3):520-8. doi: 10.1093/clinids/12.3.520.
Staphylococcus epidermidis was established as the causal agent of true bacteremia on the basis of microbiologic, epidemiologic, clinical, and prognostic data on 65 episodes of S. epidermidis bacteremia (SEB) recorded in the Hospital Covadonga of Oviedo, Spain, during 1982-1986. All isolates were susceptible in vitro to vancomycin, mercury, silver, cadmium, and malachite green, and 95.2% of isolates were susceptible to cephalothin; a dominant biotype, four resistotypes (ion-dye resistance patterns), and four antibiotypes (antibiotic resistance patterns) were found. A high percentage of isolates (76.7%) produced slime, and several potentially toxic exoproteins were detected in various and generally lower proportions. The main clinical features of SEB were high frequency in male patients greater than 40 years of age, fever, leukocytosis, anemia, and phlebitis. Indwelling devices were the most common portal of entry. The overall death rate was 36.9%. Underlying disease, hemodynamic status, predisposing factors, and treatment were statistically significant parameters in relation to mortality.
根据1982年至1986年期间西班牙奥维耶多科瓦东加医院记录的65例表皮葡萄球菌菌血症（SEB）病例的微生物学、流行病学、临床和预后数据，表皮葡萄球菌被确定为真性菌血症的病原体。所有分离株在体外对万古霉素、汞、银、镉和孔雀石绿敏感，95.2%的分离株对头孢噻吩敏感；发现了一种优势生物型、四种耐药型（离子染料耐药模式）和四种抗菌型（抗生素耐药模式）。高比例的分离株（76.7%）产生黏液，并且检测到几种潜在有毒的外蛋白，其比例各不相同且总体较低。SEB的主要临床特征为40岁以上男性患者发病率高、发热、白细胞增多、贫血和静脉炎。留置装置是最常见的感染途径。总死亡率为36.9%。基础疾病、血流动力学状态、易感因素和治疗是与死亡率相关的具有统计学意义的参数。
