Department of Occupational Diseases and Toxicology, NoferInstitute of Occupational Medicine, Lodz, Poland.
Occup Med (Lond). 2013 Jun;63(4):301-5. doi: 10.1093/occmed/kqt035. Epub 2013 Apr 18.
Chlorhexidine is a low molecular weight occupational sensitizer that can cause different delayed and immediate-type allergic reactions including anaphylaxis. It is widely used as an antiseptic and disinfectant and not only in the occupational environment as it is present in toothpaste, mouthwash, nose and eye drops and ointments. We present three cases of occupationally exposed workers with airway allergy to chlorhexidine. The role of chlorhexidine as an occupational allergen was confirmed by placebo-controlled specific inhalative challenge tests monitored by spirometry and analysis of induced sputum (influx of eosinophils after provocation has been observed). One of these patients presented with a systemic reaction with ordinary environment exposure. These findings are a reminder to clinicians of chlorhexidine's ability to cause various hypersensitivity reactions and the potential risk of this widely used antiseptic.
洗必泰是一种低分子量职业致敏原，可引起不同的迟发型和速发型过敏反应，包括过敏反应。它被广泛用作防腐剂和消毒剂，不仅在职业环境中使用，而且在牙膏、漱口水、鼻眼药水和软膏中也有使用。我们报告了三例因职业暴露而导致气道对洗必泰过敏的工人病例。通过肺功能检查和诱导痰分析（激发后观察到嗜酸性粒细胞流入）监测的安慰剂对照特异性吸入性挑战试验，证实了洗必泰作为职业过敏原的作用。其中一名患者在普通环境暴露时出现全身性反应。这些发现提醒临床医生注意洗必泰引起各种过敏反应的能力以及这种广泛使用的防腐剂的潜在风险。
