Zuntová A, Motlík K, Smelhaus V, Horejsí J
Patologicko-anatomický ústav fakulty dĕtského lékarství Univerzity Karlovy, Praha.
Sb Lek. 1990 Apr;92(4):103-9.
Granulosa cell juvenile tumours, defined in 1976 by Scully as a separate unit are found mostly in girls during the first two decades of life. On inspection under an optic microscope they are characterized by the presence of non-differentiated "blastemoid" structures and the formation of solid follicular formations and cysts. In our first case we observed a bilateral juvenile tumour made up of granulosa cells in a 8-month-old girl where the tumour produced symptoms of pseudopubertas praecox isosexualis. In the second case in a 9-month-old girl also with symptoms of pseudopubertas praecox isosexualis the authors detected in the left ovary a tumour which probably is a less differentiated variety of the juvenile granulosa cell tumour. These tumours belong into the group of little differentiated gonadal-stromal tumours with ICD-O code M-8590/1.
颗粒细胞幼年型肿瘤由斯库利在1976年定义为一个独立的类型,多见于20岁前的女孩。在光学显微镜下观察,其特征是存在未分化的“胚基样”结构以及形成实性滤泡结构和囊肿。在我们的首例病例中,一名8个月大的女孩双侧出现由颗粒细胞构成的幼年型肿瘤,该肿瘤产生了同性性早熟假性青春期的症状。在第二例病例中,一名同样有同性性早熟假性青春期症状的9个月大女孩,作者在其左卵巢中检测到一个肿瘤,该肿瘤可能是幼年型颗粒细胞瘤中分化程度较低的一种。这些肿瘤属于低分化性腺间质肿瘤组,ICD-O编码为M-8590/1。