Wang Qing-Lu, Zhang Yu-Jun, Zhou Cai-Xia, Zhang Jie, Dou Ye, Li Qiao-Qiao
Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo 255213, P.R. China.
Oncol Lett. 2013 Apr;5(4):1385-1389. doi: 10.3892/ol.2013.1155. Epub 2013 Jan 28.
Cancer hazards from pesticide residues in food have been much discussed in the past decade. In this study, we showed that dichlorvos and dimethoate affect hemoglobin content and hematocrit value, but had no effect on red blood cell counts and total plasma protein in mice. A 40-mg/kg/day dose of dichlorvos upregulated the expression of , and genes in mouse gastric tissue. By contrast, expression of the , and genes induced by low doses (5, 10 and 20 mg/kg/day) of dichlorvos demonstrated no change in the control check group (CK; 200 l sterile saline perfused group; 0 mg/kg/day). Different doses of dimethoate all upregulated the expression of , and genes in mouse gastric tissue. The results further demonstrated that mouse gastric tissue, exposed in the long-term to low doses of dichlorvos and dimethoate, has the potential to become cancerous.
过去十年间，食品中农药残留的致癌危害一直备受热议。在本研究中，我们发现敌敌畏和乐果会影响小鼠的血红蛋白含量和血细胞比容值，但对小鼠的红细胞计数和血浆总蛋白没有影响。每天40毫克/千克剂量的敌敌畏上调了小鼠胃组织中、和基因的表达。相比之下，低剂量（每天5、10和20毫克/千克）敌敌畏诱导的、和基因的表达在对照检查组（CK；200微升无菌生理盐水灌注组；每天0毫克/千克）中未发生变化。不同剂量的乐果均上调了小鼠胃组织中、和基因的表达。结果进一步表明，长期暴露于低剂量敌敌畏和乐果的小鼠胃组织有癌变的可能。
