Elbrønd H, Huniche B, Ostergaard L
Institute of Experimental Clinical Research, Arhus Municipal Hospital, Denmark.
Scand J Gastroenterol. 1990 May;25(5):534-40. doi: 10.3109/00365529009095526.
Simultaneous recordings of pressure and slow-wave activity were obtained from the sphincter of Oddi (SO) and the duodenum in anesthetized rabbits. Histographic analysis of the recordings was performed when the following criteria were fulfilled: 1) slow waves must be present in the EMG recordings from both compartments; and 2) only pressure recordings with sufficient pressure activity (greater than 50 peaks in 10 min) would be considered. Of 12 animals fulfilling the criteria for histographic analysis of 4 channels, a common basic-mode activity was found in all channels in 9 animals (75%). Of three animals fulfilling the criteria for histographic analysis of three channels, a common basic-mode activity was seen in all channels in all animals (100%). A correlation between the amplitude of the slow waves and the amplitude of the elicited pressure peaks in the SO was significant at a 5% level or better in 12 animals (80%). In some of the animals episodes of low-amplitude pressure activity was observed in the SO, occurring synchronously with slow waves devoid of spike activity. It is concluded that rabbit SO and duodenum are paced by slow waves with a common basic-mode activity in most animals. Slow waves may not only be the chief determinant of the contractile rhythm but may also have a certain influence on the force of the individual SO contractions. It is suggested that slow waves per se may be able to mediate contractile activity.
在麻醉的兔子身上，同时记录了Oddi括约肌（SO）和十二指肠的压力及慢波活动。当满足以下标准时，对记录进行组织学分析：1）两个腔室的肌电图记录中必须存在慢波；2）仅考虑具有足够压力活动（10分钟内大于50个峰值）的压力记录。在符合4通道组织学分析标准的12只动物中，9只动物（75%）的所有通道中都发现了共同的基本模式活动。在符合3通道组织学分析标准的3只动物中，所有动物的所有通道中都出现了共同的基本模式活动（100%）。在12只动物（80%）中，慢波幅度与SO中诱发的压力峰值幅度之间的相关性在5%水平或更好水平上具有显著性。在一些动物中，观察到SO中出现低幅度压力活动的发作，与无棘波活动的慢波同步发生。得出的结论是，在大多数动物中，兔子的SO和十二指肠由具有共同基本模式活动的慢波起搏。慢波不仅可能是收缩节律的主要决定因素，而且可能对单个SO收缩的力量也有一定影响。有人提出，慢波本身可能能够介导收缩活动。
