Seiler Gabriela S, Brown James C, Reetz Jennifer A, Taeymans Olivier, Bucknoff Melissa, Rossi Federica, Ohlerth Stefanie, Alder Daniela, Rademacher Nathalie, Drost Wm Tod, Pollard Rachel E, Travetti Olga, Pey Pascaline, Saunders Jimmy H, Shanaman Miriam M, Oliveira Cintia R, O'Brien Robert T, Gaschen Lorrie
Department of Molecular Biomedical Science, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695, USA.
J Am Vet Med Assoc. 2013 May 1;242(9):1255-9. doi: 10.2460/javma.242.9.1255.
To determine the incidence of adverse events within 24 hours after contrast-enhanced ultrasonography (CEUS) in dogs and cats and compare the risk of death within 24 hours after imaging for animals that underwent ultrasonography with and without injection of a contrast agent.
Retrospective case-control study.
750 animals (411 case dogs, 238 control dogs, 77 case cats, and 24 control cats).
At 11 institutions, medical records were reviewed of dogs and cats that had CEUS performed (cases) as were medical records of dogs and cats with clinical signs similar to those of case animals that had ultrasonography performed without injection of a contrast agent (controls). Information regarding signalment; preexisting disease; type, dose, and administration route of contrast agent used; immediate (within 1 hour after CEUS) and delayed (> 1 and ≤ 24 hours after CEUS) adverse events; and occurrence and cause of death (when available) was extracted from each medical record. Risk of death within 24 hours after ultrasonography was compared between case and control animals.
Of the 411 case dogs, 3 had immediate adverse events (vomiting or syncope) and 1 had a delayed adverse event (vomiting). No adverse events were recorded for case cats. Twenty-three of 357 (6.4%) clinically ill case animals and 14 of 262 (5.3%) clinically ill control animals died within 24 hours after ultrasonography; risk of death did not differ between cases and controls.
Results indicated that CEUS was safe in dogs and cats.
确定犬猫对比增强超声检查（CEUS）后24小时内不良事件的发生率，并比较注射和未注射造影剂的动物在超声检查后24小时内的死亡风险。
回顾性病例对照研究。
750只动物（411只病例犬、238只对照犬、77只病例猫和24只对照猫）。
在11家机构，回顾了接受CEUS检查的犬猫（病例）的病历，以及有与病例动物相似临床症状但未注射造影剂进行超声检查的犬猫（对照）的病历。从每份病历中提取有关动物特征、既往疾病、所用造影剂的类型、剂量和给药途径、即刻（CEUS后1小时内）和延迟（CEUS后>1小时且≤24小时）不良事件以及死亡情况和原因（如可获得）的信息。比较病例组和对照组动物超声检查后24小时内的死亡风险。
411只病例犬中，3只出现即刻不良事件（呕吐或晕厥），1只出现延迟不良事件（呕吐）。病例猫未记录到不良事件。357只临床患病的病例动物中有23只（6.4%）和262只临床患病的对照动物中有14只（5.3%）在超声检查后24小时内死亡；病例组和对照组的死亡风险无差异。
结果表明CEUS对犬猫是安全的。
