IL-6 多态性与类风湿关节炎/1 型糖尿病无关：一项荟萃分析。
Lack of association of IL-6 polymorphism with rheumatoid arthritis/type 1 diabetes: a meta-analysis.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81, Meishan Road, Hefei, 230032 Anhui, PR China.
出版信息
Joint Bone Spine. 2013 Oct;80(5):477-81. doi: 10.1016/j.jbspin.2012.11.005. Epub 2013 Apr 16.
OBJECTIVE
The aim of this study was to determine whether the interleukin (IL)-6 -174 single nucleotide polymorphism confers susceptibility to rheumatoid arthritis (RA) and type 1 diabetes (T1D) in multiple ethnic populations.
METHODS
A meta-analysis was conducted on the association between the IL-6 -174 polymorphism and RA/T1D susceptibility, using fixed and random effects models.
RESULTS
Thirteen studies were included in the meta-analysis: RA: seven studies, including six European and one Asian population; T1D: six studies, including five European and one South American population. There was no significant association both in allele and genotype comparisons between the IL-6 -174 polymorphism and RA/T1D in all study subjects. Moreover, meta-analysis stratified by ethnicity indicated no significant association between the gene and RA/T1D.
CONCLUSIONS
This meta-analysis suggests that the IL-6 -174 polymorphism might not confer susceptibility to RA/T1D.
目的
本研究旨在确定白细胞介素（IL）-6-174 单核苷酸多态性是否会导致多种族人群患类风湿关节炎（RA）和 1 型糖尿病（T1D）。
方法
采用固定效应模型和随机效应模型对 IL-6-174 多态性与 RA/T1D 易感性之间的关系进行了荟萃分析。
结果
荟萃分析共纳入 13 项研究：RA：7 项研究，包括 6 项欧洲人群和 1 项亚洲人群研究；T1D：6 项研究，包括 5 项欧洲人群和 1 项南美洲人群研究。在所有研究对象中，IL-6-174 多态性与 RA/T1D 的等位基因和基因型比较均无显著相关性。此外，按种族分层的荟萃分析表明，该基因与 RA/T1D 之间无显著相关性。
结论
本荟萃分析提示 IL-6-174 多态性可能与 RA/T1D 的易感性无关。
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