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缺血后大鼠脑内血管内皮生长因子-B的表达

Vascular endothelial growth factor-B expression in postischemic rat brain.

作者信息

Xie Lin, Mao Xiaoou, Jin Kunlin, Greenberg David A

机构信息

Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.

Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA ; Department of Pharmacology & Neuroscience, University of North Texas, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

出版信息

Vasc Cell. 2013 Apr 20;5:8. doi: 10.1186/2045-824X-5-8. eCollection 2013.

DOI:10.1186/2045-824X-5-8
PMID:23601533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3671984/
Abstract

BACKGROUND

Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.

METHODS

We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.

RESULTS

VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.

CONCLUSIONS

These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.

摘要

背景

血管内皮生长因子-B（VEGF-B）可预防实验性中风，但中风对VEGF-B表达的影响尚不确定。

方法

我们通过免疫组织化学检测了大鼠大脑中动脉闭塞后1-7天缺血边缘区的VEGF-B表达。

结果

大脑中动脉闭塞后，边缘区的VEGF-B免疫反应性增加，且与神经元和巨噬细胞/小胶质细胞有关，而与星形胶质细胞或内皮细胞无关。

结论

这些发现为VEGF-B在脑缺血内源性反应中的作用提供了额外证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b635/3671984/1483a7655f54/2045-824X-5-8-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b635/3671984/b1231209c63a/2045-824X-5-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b635/3671984/1483a7655f54/2045-824X-5-8-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b635/3671984/b1231209c63a/2045-824X-5-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b635/3671984/1483a7655f54/2045-824X-5-8-2.jpg

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