缺血后大鼠脑内血管内皮生长因子-B的表达
Vascular endothelial growth factor-B expression in postischemic rat brain.
作者信息
Xie Lin, Mao Xiaoou, Jin Kunlin, Greenberg David A
机构信息
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA ; Department of Pharmacology & Neuroscience, University of North Texas, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
出版信息
Vasc Cell. 2013 Apr 20;5:8. doi: 10.1186/2045-824X-5-8. eCollection 2013.
BACKGROUND
Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.
METHODS
We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.
RESULTS
VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.
CONCLUSIONS
These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.
背景
血管内皮生长因子-B（VEGF-B）可预防实验性中风，但中风对VEGF-B表达的影响尚不确定。
方法
我们通过免疫组织化学检测了大鼠大脑中动脉闭塞后1-7天缺血边缘区的VEGF-B表达。
结果
大脑中动脉闭塞后，边缘区的VEGF-B免疫反应性增加，且与神经元和巨噬细胞/小胶质细胞有关，而与星形胶质细胞或内皮细胞无关。
结论
这些发现为VEGF-B在脑缺血内源性反应中的作用提供了额外证据。
Zotero 插件