Fan Yishu, Lv Xinyi, Chen Zhuohui, Peng Yanyi, Zhang Mengqi
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Mol Neurosci. 2023 Feb 21;16:1102147. doi: 10.3389/fnmol.2023.1102147. eCollection 2023.
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotic cells, which participates in the functional regulation of various biological processes. It regulates the expression of targeted genes by affecting RNA translocation, alternative splicing, maturation, stability, and degradation. As recent evidence shows, of all organs, brain has the highest abundance of m6A methylation of RNAs, which indicates its regulating role in central nervous system (CNS) development and the remodeling of the cerebrovascular system. Recent studies have shown that altered m6A levels are crucial in the aging process and the onset and progression of age-related diseases. Considering that the incidence of cerebrovascular and degenerative neurologic diseases increase with aging, the importance of m6A in neurological manifestations cannot be ignored. In this manuscript, we focus on the role of m6A methylation in aging and neurological manifestations, hoping to provide a new direction for the molecular mechanism and novel therapeutic targets.
N6-甲基腺苷（m6A）是真核细胞中最丰富的内部RNA修饰，它参与各种生物过程的功能调节。它通过影响RNA转运、可变剪接、成熟、稳定性和降解来调节靶基因的表达。最新证据表明，在所有器官中，大脑中RNA的m6A甲基化丰度最高，这表明其在中枢神经系统（CNS）发育和脑血管系统重塑中的调节作用。最近的研究表明，m6A水平的改变在衰老过程以及与年龄相关疾病的发生和发展中至关重要。鉴于脑血管疾病和退行性神经疾病的发病率随年龄增长而增加，m6A在神经表现中的重要性不容忽视。在本手稿中，我们重点关注m6A甲基化在衰老和神经表现中的作用，希望为分子机制和新的治疗靶点提供新的方向。
