Department of Urology, Cheil General Hospital, Kwandong University College of Medicine, Jung-gu, Seoul, Korea.
Urology. 2013 Jun;81(6):1219-24. doi: 10.1016/j.urology.2013.02.044. Epub 2013 Apr 18.
To assess the relationship between mycoplasma infection and human infertility, we determined the concordance of Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) detection in infertile and fertile couples, and assessed semen parameters in both groups.
Fifty infertile couples without a female factor attending a fertility clinic and 48 fertile couples were randomly screened for UU and MH. The concordance between partners was compared between the fertile and infertile groups. Semen and endocervical specimens were evaluated using the commercially available Mycofast Evolution2 test.
UU was detected in 24 semen specimens (48%) from the infertile men, in 12 specimens from fertile men (25%), in 20 endocervical specimens from infertile women (40%), and 11 from fertile women (22.9%). UU was detected higher in infertile men than in fertile men (P = .022). The concordance of UU was higher in infertile couples (32%) than in fertile couples (12.5%, P = .022). The concordance of MH between male and female partners in the 2 groups did not differ significantly. The mean values of total motility, progressive motility, normal morphology, vitality, and total motile sperm count were significantly lower in sperm from infertile men than from fertile men. Progressive motility and vitality were significantly lower in UU-positive men than in men without UU, and low total motility and total motile sperm count were significantly related to the presence of MH.
Clinicians should consider the roles of UU and MH in infertility and routinely screen infertile couples for the presence of these mycoplasma species.
为了评估支原体感染与人类不育之间的关系，我们确定了不育和生育夫妇中解脲脲原体（UU）和人型支原体（MH）检测的一致性，并评估了两组的精液参数。
随机筛选了 50 对无女性因素的不育夫妇和 48 对生育夫妇进行 UU 和 MH 检测。比较了生育组和不育组之间伴侣之间的一致性。使用市售的 Mycofast Evolution2 测试对精液和宫颈标本进行评估。
UU 在 24 份不育男性精液标本（48%）、12 份生育男性标本（25%）、20 份不育女性宫颈标本（40%）和 11 份生育女性标本（22.9%）中被检出。不育男性 UU 的检出率高于生育男性（P=0.022）。不育夫妇 UU 的一致性高于生育夫妇（32%对 12.5%，P=0.022）。两组中男性和女性伴侣之间 MH 的一致性没有显著差异。不育男性的总活力、前向运动精子活力、正常形态、活力和总可动精子计数的平均值明显低于生育男性。UU 阳性男性的前向运动精子活力和活力明显低于无 UU 男性，低总活力和总可动精子计数与 MH 的存在显著相关。
临床医生应考虑 UU 和 MH 在不育症中的作用，并常规筛查不育夫妇是否存在这些支原体。
