Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Nat Med. 2013 May;19(5):631-4. doi: 10.1038/nm.3017. Epub 2013 Apr 21.
The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.
先前在成年人体内观察到的锁骨上褐色脂肪组织 (BAT) 沉积被普遍认为相当于小型哺乳动物的肩胛间产热器官。这种观点最近因以下发现而受到质疑：该沉积由米色（也称为明亮）褐色脂肪细胞组成，这是一种新发现的褐色脂肪细胞类型，与构成其他哺乳动物肩胛间产热器官的经典褐色脂肪细胞不同。高分辨率成像技术以及组织学和生化分析的组合为在人类婴儿中存在解剖上可区分的肩胛间 BAT (iBAT) 沉积提供了证据，该沉积由经典褐色脂肪细胞组成，迄今尚未证明这种细胞类型存在于人类中。基于这些发现，我们得出结论，婴儿与啮齿动物类似，具有真正的 iBAT 产热器官，由经典褐色脂肪细胞组成，这对于小型哺乳动物在寒冷环境中的生存至关重要。
