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使用 Gafchromic 胶片在 HDR 近距离治疗宫颈癌计划中直接重建和关联 192Ir 源驻留位置的不确定性,环形施源器。

Direct reconstruction and associated uncertainties of 192Ir source dwell positions in ring applicators using gafchromic film in the treatment planning of HDR brachytherapy cervix patients.

机构信息

The Medical Physics Department, The James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK.

出版信息

Phys Med Biol. 2013 May 21;58(10):3207-25. doi: 10.1088/0031-9155/58/10/3207. Epub 2013 Apr 19.

DOI:10.1088/0031-9155/58/10/3207
PMID:23603854
Abstract

This paper details a practical method for the direct reconstruction of high dose rate (192)Ir source dwell positions in ring applicators using gafchromic film in the treatment planning of brachytherapy cervix patients. It also details the uncertainties associated with such a process. Eight Nucletron interstitial ring applicators-Ø26 mm (×4), Ø30 mm (×3) and Ø34 mm (×1), and one 60 mm intrauterine tube were used in this study. RTQA2 and XRQA2 gafchromic films were irradiated at pre-programmed dwell positions with three successive (192)Ir sources and used to derive the coordinates of the source dwell positions. The source was observed to deviate significantly from its expected position by up to 6.1 mm in all ring sizes. Significant inter applicator differences of up to 2.6 mm were observed between a subset of ring applicators. Also, the measured data were observed to differ significantly from commercially available source path models provided by Nucletron with differences of up to 3.7 mm across all ring applicator sizes. The total expanded uncertainty (k = 2) averaged over all measured dwell positions in the rings was observed to be 1.1 ± 0.1 mm (Ø26 mm and Ø30 mm rings) and 1.0 ± 0.3 mm (Ø34 mm ring) respectively, and when transferred to the treatment planning system, equated to maximum %dose changes of 1.9%, 13.2% and 1.5% at regions representative of the parametrium, lateral fornix and organs at risk respectively.

摘要

本文详细介绍了一种实用的方法,用于在宫颈癌近距离治疗计划中使用 Gafchromic 胶片直接重建环施源器中高剂量率(192)Ir 源驻留位置。它还详细说明了与该过程相关的不确定性。本研究使用了 8 个 Nucletron 间质环施源器(Ø26mm(×4)、Ø30mm(×3)和 Ø34mm(×1),以及一个 60mm 宫内管。RTQA2 和 XRQA2 Gafchromic 胶片在预编程的驻留位置上用三个连续的(192)Ir 源照射,并用于得出源驻留位置的坐标。结果观察到源在所有环尺寸上的实际位置偏离其预期位置高达 6.1mm。在一组环施源器之间观察到高达 2.6mm 的显著施源器间差异。此外,观察到测量数据与 Nucletron 提供的商业上可用的源路径模型有显著差异,在所有环施源器尺寸上的差异高达 3.7mm。在环中的所有测量驻留位置上,总扩展不确定度(k = 2)平均为 1.1 ± 0.1mm(Ø26mm 和 Ø30mm 环)和 1.0 ± 0.3mm(Ø34mm 环),当转移到治疗计划系统时,在相当于代表宫旁组织、外侧穹窿和危险器官的区域的最大剂量变化分别为 1.9%、13.2%和 1.5%。

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