Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.
Nutrients. 2013 Apr 19;5(4):1349-65. doi: 10.3390/nu5041349.
Selenium was considered a toxin until 1957, when this mineral was shown to be essential in the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention is principally formulated by the observations that cancer incidence is inversely associated with selenium status. However, recent clinical and epidemiological studies demonstrate a role for some selenoproteins in exacerbating or promoting other disease states, specifically type 2 diabetes, although other data support a role of selenium in stimulating insulin sensitivity. Therefore, it is clear that our understanding in the role of selenium in glucose metabolism and chemoprevention is inadequate and incomplete. Research exploring the role of selenium in individual healthcare is of upmost importance and possibly will help explain how selenium is a double-edged sword in the pathologies of chronic diseases.
硒曾被认为是一种毒素,直到 1957 年,人们发现这种矿物质对预防大鼠肝坏死是必不可少的。硒化学预防假说主要是基于以下观察结果提出的:癌症发病率与硒的状态呈负相关。然而,最近的临床和流行病学研究表明,一些硒蛋白在加剧或促进其他疾病状态(特别是 2 型糖尿病)方面起作用,尽管其他数据支持硒在刺激胰岛素敏感性方面的作用。因此,很明显,我们对硒在葡萄糖代谢和化学预防中的作用的理解是不充分和不完善的。研究探索硒在个体保健中的作用至关重要,可能有助于解释硒在慢性病的病理中是一把双刃剑。