年龄对人类细胞因子产生的影响。
Effect of age on cytokine production in humans.
作者信息
Bernstein E D, Murasko D M
出版信息
Age (Omaha). 1998 Oct;21(4):137-51. doi: 10.1007/s11357-998-0024-6.
Abstract
Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFNγ) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 studies in humans suggests that age-associated changes in cytokine production are not consistent.
摘要
衰老伴随着免疫反应的诸多变化，其中最一致且显著的改变发生在T细胞区室。由于细胞因子是免疫细胞通讯的核心，细胞因子产生方面与年龄相关的变化可能导致了这些改变。虽然来自小鼠研究的数据表明细胞因子反应从Th1（白细胞介素-2、干扰素γ）转变为Th2（白细胞介素-4、白细胞介素-6、白细胞介素-10），但该模型在人类中尚未得到如此明确的确立。此外，本次对50多项人类研究的综述表明，细胞因子产生方面与年龄相关的变化并不一致。
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