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不同酵母菌株对赭曲霉毒素 A 解毒能力的研究。

Investigation of different yeast strains for the detoxification of ochratoxin A.

机构信息

Biomin IAN GmbH, Industriestrasse 21, A-3130, Herzogenburg.

出版信息

Mycotoxin Res. 2003 Jun;19(2):124-8. doi: 10.1007/BF02942950.

DOI:10.1007/BF02942950
PMID:23604763
Abstract

High concentrations of ochratoxin A (OTA) in feed lead to growth depression in animals. It has been reported that binders can be used for deactivating aflatoxins but not for other mycotoxins without negatively influencing the animals health. In this study a strain from the genus ofTrichosporon with the ability to cleave ochratoxin A very selectively into phenylalanine and the non-toxic ochratoxin α (OTα) could be isolated. This strain was selected from a pool of OTA detoxifying microorganism by carrying out several investigations.Trichosporon sp. nov. can be fermented and stabilized. In a feeding trial with broilers lyophilizedTrichosporon-cells could compensate performance losses caused by OTA.

摘要

高浓度的赭曲霉毒素 A(OTA)在饲料中会导致动物生长抑制。据报道,黏合剂可用于使黄曲霉毒素失活,但不能用于其他霉菌毒素,而不会对动物健康产生负面影响。在这项研究中,从一种能够非常选择性地将赭曲霉毒素 A 切割成苯丙氨酸和无毒的赭曲霉毒素α(OTα)的曲霉菌属中分离出一种具有这种能力的菌株。该菌株是通过进行多项研究从 OTA 解毒微生物池中选择出来的。可以发酵和稳定地生产新型曲霉菌。在一项肉鸡饲养试验中,冻干的新型曲霉菌细胞可以补偿由 OTA 引起的生产性能损失。

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Evidence of ochratoxin A-detoxification activity of rumen fluid, intestinal fluid and soil samples as well as isolation of relevant microorganisms from these environments.瘤胃液、肠液和土壤样品中 ochratoxin A 解毒活性的证据,以及从这些环境中分离相关微生物。
Mycotoxin Res. 2002 Jun;18 Suppl 2:183-7. doi: 10.1007/BF02946092.
天然饲料添加剂和生物活性补充剂与化学添加剂相比,是对抗食源性霉菌毒素中毒的一种安全实用方法。
Front Nutr. 2024 Feb 19;11:1335779. doi: 10.3389/fnut.2024.1335779. eCollection 2024.
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Molecular Docking and In Vitro Studies of Ochratoxin A (OTA) Biodetoxification Testing Three Endopeptidases.三种内肽酶的赭曲霉毒素 A(OTA)生物解毒检测的分子对接和体外研究。
Molecules. 2023 Feb 21;28(5):2019. doi: 10.3390/molecules28052019.
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Complete Genome Sequencing and Comparative Analysis of the Clinically-Derived Strain GMU1709.临床分离株 GMU1709 的全基因组测序及比较分析。
Front Cell Infect Microbiol. 2022 Feb 4;12:834015. doi: 10.3389/fcimb.2022.834015. eCollection 2022.
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Diversity of Mycobiota in Spanish Grape Berries and Selection of U1 to Prevent Mycotoxin Contamination.西班牙葡萄浆果中真菌群落的多样性及 U1 的选择以防止真菌毒素污染。
Toxins (Basel). 2021 Sep 13;13(9):649. doi: 10.3390/toxins13090649.
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Advances in Biodetoxification of Ochratoxin A-A Review of the Past Five Decades.赭曲霉毒素A生物解毒的进展——过去五十年综述
Front Microbiol. 2018 Jun 26;9:1386. doi: 10.3389/fmicb.2018.01386. eCollection 2018.
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