Kimura S, Yoshimoto H
Dept. of Ophthalmol., School of Med., Hirosaki Univ., Japan.
Nippon Ganka Gakkai Zasshi. 1990 Jan;94(1):18-24.
Newly formed intraretinal vessels caused by experimental renovascular hypertension were studied histopathologically in rats. In these rats, dystrophy of the outer retinal layer and disappearance of retinal small capillaries were found in correlation with the duration of hypertensive state. In particular, retina obtained from rats with severe hypertension maintained for 6 months or more showed marked tissue damage and intraretinal proliferation of pigment epithelial cell with numerous microvessels. Most of these vessels were characterized by endothelial cell with large nuclei and slit-like narrowed lumina. Similar microvessels were also frequently observed in neighboring pigment epithelial cell layer. Endothelial fenestrations were observed in these vessels, although no findings were observed suggesting vessels penetrating through Bruch's membrane from the choroid. Similar vessels were also found in the inner plexiform layer and rarely in the nerve fiber layer. They were surrounded by processes resembling basal infolding of pigment epithelial cell. However, no fenestration of endothelial cells was found in these vessels.
对实验性肾血管性高血压所致的新生视网膜内血管进行了大鼠组织病理学研究。在这些大鼠中，发现视网膜外层营养不良和视网膜小毛细血管消失与高血压状态的持续时间相关。特别是，从患有严重高血压并持续6个月或更长时间的大鼠获得的视网膜显示出明显的组织损伤以及色素上皮细胞的视网膜内增殖，并伴有大量微血管。这些血管大多以内皮细胞核大、管腔呈狭缝状狭窄为特征。在邻近的色素上皮细胞层也经常观察到类似的微血管。在这些血管中观察到内皮窗孔，尽管未观察到提示血管从脉络膜穿透布鲁赫膜的发现。在内网状层也发现了类似的血管，在神经纤维层很少见。它们被类似于色素上皮细胞基底褶皱的突起所包围。然而，在这些血管中未发现内皮细胞窗孔。
