黄酮类和非黄酮类化合物对碳曲霉生长和赭曲霉毒素 A 生物合成的抑制作用。
Inhibition of growth and ochratoxin A biosynthesis in Aspergillus carbonarius by flavonoid and nonflavonoid compounds.
机构信息
Laboratorio de Microbiología de Alimentos, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, 3° Piso, 1428, Buenos Aires, Argentina,
出版信息
Mycotoxin Res. 2009 Oct;25(3):165-70. doi: 10.1007/s12550-009-0026-y. Epub 2009 Sep 18.
The effect of naturally occurring phenolic compounds on Aspergillus carbonarius growth and ochratoxin A (OTA) production was studied. Caffeic acid and the flavonoids, rutin and quercetin, were added to Czapek Yeast Extract agar at concentrations ranging between 50 and 500 mg/l. All phenolic compounds had a significant influence on growth rate and lag phase of A. carbonarius at 250 mg/l. The growth was completely inhibited with 500 mg/l. In comparison with the control, a significant decrease in OTA production was observed with all phenolic compounds. In general, effect on growth was less evident than effect on toxin production. An inhibitory effect on growth and OTA production, as concentration was increased was observed in all cases. The response of A. carbonarius to the flavonoids, rutin and quercetin, was similar. The inhibitory effect of these natural phenolic compounds on fungal growth and OTA production could be an alternative to the use of chemical fungicides.
研究了天然存在的酚类化合物对赭曲霉（Aspergillus carbonarius）生长和赭曲霉毒素 A（OTA）产生的影响。将咖啡酸和类黄酮（芦丁和槲皮素）添加到察氏酵母提取物琼脂中，浓度范围为 50 至 500mg/L。所有酚类化合物在 250mg/L 时对 A. carbonarius 的生长率和延滞期均有显著影响。用 500mg/L 时，生长完全受到抑制。与对照相比，所有酚类化合物均显著降低了 OTA 的产生。总的来说，与毒素产生相比，对生长的影响不太明显。在所有情况下，随着浓度的增加，对生长和 OTA 产生的抑制作用均增加。A. carbonarius 对类黄酮（芦丁和槲皮素）的反应相似。这些天然酚类化合物对真菌生长和 OTA 产生的抑制作用可能是替代化学杀真菌剂的一种方法。
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