Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary.
Toxins (Basel). 2010 Jul;2(7):1718-50. doi: 10.3390/toxins2071718. Epub 2010 Jul 1.
Ochratoxins are polyketide derived fungal secondary metabolites with nephrotoxic, immunosuppressive, teratogenic, and carcinogenic properties. Ochratoxin-producing fungi may contaminate agricultural products in the field (preharvest spoilage), during storage (postharvest spoilage), or during processing. Ochratoxin contamination of foods and feeds poses a serious health hazard to animals and humans. Several strategies have been investigated for lowering the ochratoxin content in agricultural products. These strategies can be classified into three main categories: prevention of ochratoxin contamination, decontamination or detoxification of foods contaminated with ochratoxins, and inhibition of the absorption of consumed ochratoxins in the gastrointestinal tract. This paper gives an overview of the strategies that are promising with regard to lowering the ochratoxin burden of animals and humans.
赭曲霉毒素是一类多酮类衍生的真菌次生代谢产物，具有肾毒性、免疫抑制性、致畸性和致癌性。产赭曲霉毒素的真菌可能会污染田间的农产品（收获前变质）、储存期间（收获后变质）或加工过程中。食品和饲料中的赭曲霉毒素污染对动物和人类的健康构成严重威胁。已经研究了几种降低农产品中赭曲霉毒素含量的策略。这些策略可以分为三大类：防止赭曲霉毒素污染、对受赭曲霉毒素污染的食品进行脱毒或解毒，以及抑制胃肠道对摄入的赭曲霉毒素的吸收。本文概述了在降低动物和人类的赭曲霉毒素负担方面有前景的策略。
