睾酮对未成年雌性大鼠肝脏中玉米赤霉烯酮还原的诱导作用。

Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.

机构信息

Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, S-75007, Uppsala.

出版信息

Mycotoxin Res. 1985 Sep;1(2):51-6. doi: 10.1007/BF03192003.

DOI:10.1007/BF03192003

Abstract

The prepubertal responsiveness of 3α-hydroxysteroid dehydrogenase and zeara-lenone-reducing activity to either a large subcutaneous dose of testosterone or dietary zearalenone was investigated in female rats. Testosterone induced both the activity of the 3α-hydroxysteroid dehydrogenase, with androsterone as substrate, and zearalenone reduction to α- and (β-zearalenol. Zearalenone had no effect on the activity of 3α-hydroxysteroid dehydrogenase, but had a slight inducing effect on the zearalenone reduction to β-zearalenol. Both testosterone and zearalenone had a growth-promoting effect on uterus.

摘要

研究了大剂量皮下注射睾酮或饲料中玉米赤霉烯酮对雌性幼鼠 3α-羟甾脱氢酶和玉米赤霉烯酮还原活性的影响。睾酮诱导 3α-羟甾脱氢酶的活性，以雄酮为底物，并将玉米赤霉烯酮还原为α-和（β-玉米赤霉烯醇。玉米赤霉烯酮对 3α-羟甾脱氢酶的活性没有影响，但对β-玉米赤霉烯醇的玉米赤霉烯酮还原有轻微的诱导作用。睾酮和玉米赤霉烯酮对子宫均有促生长作用。