肾切除术后患者赭曲霉毒素 A 水平。

The level of ochratoxin a in patients after nephrectomy.

机构信息

Institute of Biology and Environmental Protection, Kazimierz Wielki University, Chodkiewicza 30, 85064, Bydgoszcz, Poland,

出版信息

Mycotoxin Res. 2007 Mar;23(1):22-6. doi: 10.1007/BF02946020.

DOI:10.1007/BF02946020

PMID:23605812

Abstract

Ochratoxin A (OTA) was analyzed in human serum and kidney samples, collected in Poland in the Pomeranian region from March to September 2005. OTA was determined using reversed phase liquid chromatography with fluorescence detection. The collected samples were from patients after nephrectomy (9 from men and 11 from women) and control serum samples from people without kidney diseases (3 and 3, respectively). The mean concentration OTA in serum of the healthy group was 0.37 ng/ml in both men and women. In patients subjected to nephrectomy it reached 1.06 ng/ml in men and 0.94 ng/ml in women, the mean content of ochratoxin A in kidneys was 0.23 ng/g and 0.20 ng/g, respectively. The highest concentration of OTA in serum among the patients subjected to nephrectomy was 3.77 ng/ml in men and 2.27 ng/ml in women while in kidneys 0.45 ng/g and 0.39 ng/g, respectively.

摘要

在波兰波美拉尼亚地区，于 2005 年 3 月至 9 月期间收集了人类血清和肾脏样本，用于分析赭曲霉毒素 A（OTA）。使用反相液相色谱法和荧光检测法测定 OTA。收集的样本来自肾切除术患者（男性 9 例，女性 11 例）和无肾脏疾病的对照组血清样本（男性和女性分别为 3 例和 3 例）。健康组男性和女性血清中 OTA 的平均浓度分别为 0.37ng/ml。在接受肾切除术的患者中，男性和女性的 OTA 含量分别达到 1.06ng/ml 和 0.94ng/ml，肾脏中的 OTA 含量分别为 0.23ng/g 和 0.20ng/g。接受肾切除术的患者血清中 OTA 的最高浓度分别为男性 3.77ng/ml 和女性 2.27ng/ml，而肾脏中的 OTA 含量分别为 0.45ng/g 和 0.39ng/g。