德国不同肾脏疾病患者血液中赭曲霉毒素 A 浓度的初步结果。

Preliminary results on Ochratoxin A concentrations in blood of patients with various kidney diseases in Germany.

机构信息

Physiologisches Institut, Universität Würzburg, Röntgenring 9, D-97070, Würzburg, Germany.

出版信息

Mycotoxin Res. 2001 Jun;17 Suppl 2:146-9. doi: 10.1007/BF03036424.

Abstract

Ochratoxin A (OTA) is supposed to induce renal diseases in man and animals and a correlation between renal diseases and OTA concentration in blood is suspected. Therefore, we measured OTA concentrations in blood of subjects suffering from various renal diseases as e.g. interstitial nephritis or mesangial proliferating glomerular nephritis (GN) and compared them with the blood concentration of healthy individuals. We found OTA in 87% of all samples. There was no significant difference between OTA concentrations of healthy individuals and patients but some renal diseases (e.g. chronic glomerular nephritis) showed increased numbers of samples containing more than 1.5 nmol/l OTA in sera. In contrast, in samples from patients suffering from membranous or focal-sclerotic glomerular nephritis no concentrations above 1.5 nmol/l were found. Our preliminary results show that OTA is abundant in nearly all serum samples but some renal diseases show increased numbers of samples with high (>1.5 nmol/l) OTA concentrations.

摘要

赭曲霉毒素 A（OTA）据推测会导致人类和动物的肾脏疾病，并且怀疑肾脏疾病与血液中的 OTA 浓度之间存在相关性。因此，我们测量了患有各种肾脏疾病（如间质性肾炎或系膜增生性肾小球肾炎（GN））的受试者血液中的 OTA 浓度，并将其与健康个体的血液浓度进行了比较。我们在所有样本中都发现了 OTA。健康个体和患者之间的 OTA 浓度没有显著差异，但某些肾脏疾病（例如慢性肾小球肾炎）显示出含有超过 1.5 nmol/l OTA 的样本数量增加。相比之下，在患有膜性或局灶性硬化性肾小球肾炎的患者样本中未发现超过 1.5 nmol/l 的浓度。我们的初步结果表明，OTA 在几乎所有血清样本中都很丰富，但某些肾脏疾病显示出含有高浓度（>1.5 nmol/l）OTA 的样本数量增加。