Kim Inhye, Kim Haeng-Ran, Kim Jae-Hyun, Om Ae-Son
Department of Agrofood Resources, National Academy of Agricultural Science, Rural Development Administration, Suwon, 441-853, Republic of Korea.
J Sci Food Agric. 2013 Aug 30;93(11):2749-57. doi: 10.1002/jsfa.6094. Epub 2013 Apr 19.
This study was designed to examine the potential health benefits of Allium sativum L. (garlic) stem extract (ASSE) on obesity and related disorders in high-fat diet-induced obese mice. Obese mice were orally administered ASSE at doses of 100, 250 and 500 mg kg(-1) body weight day(-1) for 4 weeks.
Consumption of ASSE significantly suppressed body weight gain and white adipose tissue (WAT) weight regardless of daily food intake. Obese mice fed ASSE also exhibited a significant decrease in WAT cell size. The decreased level of adiponectin and increased level of leptin in obese mice reverted to near normal mice levels in ASSE-treated mice. ASSE administration significantly improved lipid parameters of the serum and liver and inhibited fat accumulation in the liver by modulating the activities of hepatic lipid-regulating enzymes in obese mice. Administration of ASSE also led to significant increases in antioxidant enzymes and suppressed glutathione depletion and lipid peroxidation in hepatic tissue.
These results suggest that ASSE may ameliorate obesity, insulin resistance and oxidative damage in high-fat diet-induced obese mice.
本研究旨在探讨大蒜茎提取物（ASSE）对高脂饮食诱导的肥胖小鼠肥胖及相关疾病的潜在健康益处。肥胖小鼠按体重每日100、250和500mg/kg的剂量口服ASSE，持续4周。
无论每日食物摄入量如何，食用ASSE均能显著抑制体重增加和白色脂肪组织（WAT）重量。喂食ASSE的肥胖小鼠的WAT细胞大小也显著减小。肥胖小鼠中脂联素水平降低和瘦素水平升高在ASSE处理的小鼠中恢复到接近正常小鼠的水平。ASSE给药显著改善了血清和肝脏的脂质参数，并通过调节肥胖小鼠肝脏脂质调节酶的活性抑制了肝脏中的脂肪积累。ASSE给药还导致抗氧化酶显著增加，并抑制了肝组织中的谷胱甘肽消耗和脂质过氧化。
这些结果表明，ASSE可能改善高脂饮食诱导的肥胖小鼠的肥胖、胰岛素抵抗和氧化损伤。
