Department of Research & Development, Chlorella Industry Co., Ltd., 1343 Hisatomi, Chikugo, Fukuoka 833-0056, Japan.
Department of Research & Development, Chlorella Industry Co., Ltd., 1343 Hisatomi, Chikugo, Fukuoka 833-0056, Japan.
Obes Res Clin Pract. 2013 Mar-Apr;7(2):e95-e105. doi: 10.1016/j.orcp.2013.01.002.
Obesity-induced glucose and lipid metabolism disorders have become risk factors for lifestyle diseases. Powderized Parachlorella beijerinckii (BP) and its hot water extract (BCEx) are believed to be useful for preventing common diseases such as hypertension, arteriosclerosis, and hyperlipidemia. The present study investigated how chlorella components influence common diseases in obese mice and rats on a high-fat diet.
We fed C57BL/6J mice a high-fat diet containing 5% BP, and then weighed their organs, tested their glucose tolerance and insulin sensitivity, and analyzed their serum. Further, we fed Sprague-Dawley rats with a high-fat diet containing 1% BCEx, and then weighed their organs and analyzed their serum parameters.
BP administration had no effect on high-fat diet-induced obesity. However, compared with high-fat diet group, BP group had improved glucose tolerance and insulin sensitivity and inhibited the hypertrophic growth of visceral fat cells. In addition, BP group had improved serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels. The MCP-1 expression level at epididymal fat was decreased at BP group. BCEx administration reduced amount of peritesticular fat and serum triglyceride (TG) levels.
The results suggest that the antihyperinsulinemic effects of BP are due to the modulation of adipose tissue hypertrophy and adipocytokine secretion. BCEx inhibited the accumulation of visceral fat and serum TG. The study showed that BP and BCEx improve glucose and lipid metabolism disorders caused by a high-fat diet.
肥胖引起的糖、脂代谢紊乱已成为生活方式病的危险因素。粉状柏氏巴夫藻（BP）及其热水提取物（BCEx）被认为对预防高血压、动脉硬化和高脂血症等常见疾病有一定作用。本研究探讨了小球藻成分如何影响高脂肪饮食肥胖小鼠和大鼠的常见疾病。
我们用含 5% BP 的高脂肪饲料喂养 C57BL/6J 小鼠，称其器官重量，检测其葡萄糖耐量和胰岛素敏感性，并分析其血清。进一步，我们用含 1% BCEx 的高脂肪饲料喂养 Sprague-Dawley 大鼠，称其器官重量，分析其血清参数。
BP 给药对高脂肪饮食诱导的肥胖没有影响。然而，与高脂肪饮食组相比，BP 组的葡萄糖耐量和胰岛素敏感性提高，内脏脂肪细胞的肥大生长受到抑制。此外，BP 组的血清脂联素、瘦素和单核细胞趋化蛋白-1（MCP-1）水平也有所改善。BP 组附睾脂肪组织中 MCP-1 的表达水平降低。BCEx 给药减少了附睾周围脂肪量和血清三酰甘油（TG）水平。
结果表明，BP 的抗高胰岛素血症作用是由于调节脂肪组织肥大和脂肪细胞因子的分泌。BCEx 抑制了内脏脂肪的蓄积和血清 TG。研究表明，BP 和 BCEx 改善了高脂肪饮食引起的糖、脂代谢紊乱。
