Laboratory of Neurology, Institute of Integrative Medicine, Zhongshan Hospital, Fudan University, 180, Fenglin Road, Shanghai, 200032, China.
Transl Neurodegener. 2013 Apr 22;2(1):9. doi: 10.1186/2047-9158-2-9.
To quantitatively evaluate severity of behavioral and psychological symptoms of dementia (BPSD) for vascular dementia (VD). Changes of 51 patients with VD in BPSD between the first and 24th week were assessed using the Neuropsychiatric Inventory (NPI) and the behavioral pathology in Alzheimer's disease (BEHAVE-AD) rating scale, in detrended fluctuation analysis (DFA) represented by diurnal activity (DA), evening activity (EA), and nocturnal activity (NA), and the relationships were analyzed. The subscores of activity disturbances, diurnal rhythm disturbances, and anxieties and phobias in the BEHAVE-AD score, and that of agitation, irritability, and sleep disorder in the NPI score were significantly increased compared with the first week, as was for the changes for EA in the DFA value. A linear correlation was observed between the changes of activity disturbances plus anxieties and phobias, and those of DA, and between the development of diurnal rhythm and those of EA, the vehement and autism scores and those of DA, and the difference in sleep disorder scores and those of EA, respectively. Analysis of DA, NA, and EA may reflect the fluctuational degrees of VD-BPSD, can provide a useful assessment of VD-BPSD accompanied by clinical scores for VD.
为定量评估血管性痴呆（VD）患者的行为和心理症状的严重程度（BPSD）。采用神经精神问卷（NPI）和阿尔茨海默病行为病理评定量表（BEHAVE-AD）评估 51 例 VD 患者 BPSD 在第 1 周至第 24 周的变化，用去趋势波动分析（DFA）表示昼夜活动（DA）、傍晚活动（EA）和夜间活动（NA），并分析其关系。BEHAVE-AD 评分中的活动障碍、昼夜节律障碍和焦虑和恐惧的亚评分，以及 NPI 评分中的激动、易怒和睡眠障碍的亚评分，与第 1 周相比显著增加，DFA 值中 EA 的变化也是如此。活动障碍加焦虑和恐惧的变化与 DA 的变化之间，以及昼夜节律的发展与 EA 的变化之间，以及躁动和自闭症评分与 DA 的变化之间，以及睡眠障碍评分与 EA 的变化之间均呈线性相关。DA、NA 和 EA 的分析可能反映了 VD-BPSD 的波动程度，可以为伴有 VD 临床评分的 VD-BPSD 提供有用的评估。
