International Hair Research Foundation (IHRF), Milan, Italy.
Br J Dermatol. 2013 Sep;169(3):690-4. doi: 10.1111/bjd.12397.
Alopecia areata (AA) is a common autoimmune condition, causing inflammation-induced hair loss. This disease has very limited treatment possibilities, and no treatment is either curative or preventive. Platelet-rich plasma (PRP) has emerged as a new treatment modality in dermatology, and preliminary evidence has suggested that it might have a beneficial role in hair growth.
To evaluate the efficacy and safety of PRP for the treatment of AA in a randomized, double-blind, placebo- and active-controlled, half-head, parallel-group study.
Forty-five patients with AA were randomized to receive intralesional injections of PRP, triamcinolone acetonide (TrA) or placebo on one half of their scalp. The other half was not treated. Three treatments were given for each patient, with intervals of 1 month. The endpoints were hair regrowth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki-67 evaluation. Patients were followed for 1 year.
PRP was found to increase hair regrowth significantly and to decrease hair dystrophy and burning or itching sensation compared with TrA or placebo. Ki-67 levels, which served as markers for cell proliferation, were significantly higher with PRP. No side-effects were noted during treatment.
This pilot study, which is the first to investigate the effects of PRP on AA, suggests that PRP may serve as a safe and effective treatment option in AA, and calls for more extensive controlled studies with this method.
斑秃（AA）是一种常见的自身免疫性疾病，可导致炎症性脱发。这种疾病的治疗方法非常有限，没有一种治疗方法是既治愈又预防的。富血小板血浆（PRP）已成为皮肤科的一种新的治疗方式，初步证据表明，它可能在毛发生长中发挥有益作用。
在一项随机、双盲、安慰剂和活性对照、半头、平行组研究中，评估 PRP 治疗 AA 的疗效和安全性。
45 例 AA 患者随机分为 PRP、曲安奈德（TrA）或安慰剂组，在头皮的一半进行皮内注射。另一半不治疗。每位患者接受 3 次治疗，间隔 1 个月。终点是毛发生长、皮肤镜下评估的毛发结构不良、烧灼感或瘙痒感以及通过 Ki-67 评估的细胞增殖。患者随访 1 年。
与 TrA 或安慰剂相比，PRP 显著增加了毛发生长，减少了毛发结构不良和烧灼感或瘙痒感。作为细胞增殖标志物的 Ki-67 水平在 PRP 组显著升高。治疗过程中未出现不良反应。
这是第一项研究 PRP 对 AA 影响的初步研究，表明 PRP 可能是一种安全有效的 AA 治疗选择，并呼吁对这种方法进行更广泛的对照研究。
