Starkstein S E, Mayberg H S, Berthier M L, Fedoroff P, Price T R, Dannals R F, Wagner H N, Leiguarda R, Robinson R G
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Ann Neurol. 1990 Jun;27(6):652-9. doi: 10.1002/ana.410270612.
We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). While the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.
