Department of Dermatology, Hospital de Sant Pau, C/ Sant Antoni Maria Claret, 167, 08025 Barcelona, Spain.
Eur J Dermatol. 2013 Apr 1;23(2):233-40. doi: 10.1684/ejd.2013.2003.
Several acne grading systems have been described, but consensus is lacking on which shows superiority. A standardized system would facilitate therapeutic decisions and the analysis of clinical trial data.
To assess the feasibility, reliability, validity and sensitivity to change of the Spanish Acne Severity Scale (EGAE).
MATERIALS & METHODS: A Spanish, multicentre, prospective, observational study was performed in patients with facial, back or chest acne assessed using EGAE, Leeds Revised Acne Grading system (LRAG) and lesion count. Clinicians answered 4 questions regarding EGAE use and time employed. Patients were evaluated at baseline and after 5±1 weeks. Four additional blinded observers, all dermatologists, evaluated patients' pictures using EGAE and LRAG.
In total, 349 acne locations were assessed in 328 patients. Of the dermatologists, 95.6% (CI: 92.9-97.5%) reported that EGAE was easy to use, and 75% used it in <3 minutes. Interobserver reliability of the EGAE scale was shown by a Kendall's W of 0.773 (p<0.001). EGAE and LRAG scales showed a high correlation (Spearman's correlation>0.85; p<0.001). EGAE mean score in treatment-compliant patients was significantly lower at follow-up than at baseline (2.14 vs. 1.57, p<0.001, Cohen's d=0.35).The pre-post-treatment difference in EGAE mean score in non-compliant patients was not significant (1.44 vs. 1.32, p<0.102) and Cohen's d was lower (0.19) than in compliant patients.
The use of EGAE to evaluate acne grade in daily clinical dermatological practice in Spanish centres has shown feasibility, high interobserver reliability, concurrent validity and sensitivity to detect treatment effects.
已经描述了几种痤疮分级系统，但缺乏哪种系统具有优越性的共识。标准化系统将有助于治疗决策和临床试验数据的分析。
评估西班牙痤疮严重程度分级系统（EGAE）的可行性、可靠性、有效性和对变化的敏感性。
在西班牙，进行了一项多中心、前瞻性、观察性研究，使用 EGAE、利兹修订痤疮分级系统（LRAG）和病变计数评估面部、背部或胸部痤疮的患者。临床医生回答了 4 个关于 EGAE 使用和所花费时间的问题。患者在基线和 5±1 周后进行评估。另外 4 名盲法观察员，均为皮肤科医生，使用 EGAE 和 LRAG 评估患者的图片。
总共评估了 328 名患者的 349 个痤疮部位。皮肤科医生中，95.6%（CI：92.9-97.5%）报告 EGAE 易于使用，75%的医生在 <3 分钟内使用它。EGAE 量表的观察者间可靠性通过 Kendall 的 W 为 0.773（p<0.001）表示。EGAE 和 LRAG 量表之间显示出高度相关性（Spearman 相关系数>0.85；p<0.001）。在治疗依从性患者中，随访时 EGAE 平均评分明显低于基线时（2.14 与 1.57，p<0.001，Cohen's d=0.35）。在不依从患者中，EGAE 平均评分的治疗前后差异无统计学意义（1.44 与 1.32，p<0.102），Cohen's d 较低（0.19）。
在西班牙中心的日常临床皮肤科实践中使用 EGAE 评估痤疮等级具有可行性、高观察者间可靠性、同时有效性和检测治疗效果的敏感性。
