Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.
Oral Oncol. 2011 Sep;47(9):866-72. doi: 10.1016/j.oraloncology.2011.06.015. Epub 2011 Jul 8.
The highest rates of oral squamous cell carcinomas are observed in south Asia, particularly in India, where complex forms of tobacco and alcohol exposures exist. Genetic polymorphisms contribute significantly to observed differences in cancer susceptibility. We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls. GSTT1 null and rs1695 were inversely associated with oral leukoplakia while GSTM1 null, GSTT1 null, rs2031920, rs3813867 (CYP2E1), and rs13181 were associated with OC. We report that genetic variants associated with premalignant and malignant conditions of the oral cavity differ. The associations appeared to be consistent among smokeless tobacco users, a characteristic risk factor in these parts.
口腔鳞状细胞癌的发病率最高见于南亚，尤其是在印度，那里存在复杂的烟草和酒精暴露形式。遗传多态性对癌症易感性的观察到的差异有重要贡献。我们研究了八个基因（rs4646903、rs2031920、rs3813867、GSTM1 缺失、GSTT1 缺失、rs1695、rs1138272、rs1799782、rs25487、rs1799791、rs1799793、rs13181 和 rs1052133）中 13 个变体与烟草和酒精代谢的各个阶段以及在涉及 219 例口腔白斑、665 例口腔癌和 802 例年龄、性别和习惯匹配对照的病例对照研究中口腔白斑和口腔癌（OC）的风险之间的关联。GSTT1 缺失和 rs1695 与口腔白斑呈负相关，而 GSTM1 缺失、GSTT1 缺失、rs2031920、rs3813867（CYP2E1）和 rs13181 与 OC 相关。我们报告与口腔癌前和恶性病变相关的遗传变异不同。在这些地区作为特征性危险因素的无烟气烟草使用者中，关联似乎是一致的。
