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基于人群的卵磷脂胆固醇酰基转移酶(LCAT)参考值。

Population-based reference values for lecithin-cholesterol acyltransferase (LCAT).

作者信息

Albers J J, Bergelin R O, Adolphson J L, Wahl P W

出版信息

Atherosclerosis. 1982 Jun;43(2-3):369-79. doi: 10.1016/0021-9150(82)90036-3.

Abstract

Plasma unesterified cholesterol is converted to cholesteryl ester by the enzyme lecithin-cholesterol acyltransferase (LCAT). Plasma levels of LCAT were measured by a sensitive double antibody radioimmunoassay in a sample from an adult employee population, ages 20-59 years, in the Pacific Northwest. After adjusting for differences in relative body mass, women had significantly higher LCAT levels (5.90 +/- 1.06, n = 154) than men (5.49 +/- 0.89, n = 83). For ages 20-59 years, LCAT levels showed a slight association with age: r = 0.13 for men and 0.29 for women. LCAT was positively correlated with relative body mass, total cholesterol, and LDL cholesterol. Men who smoked cigarettes had significantly lower LCAT mass than men who did not smoke cigarettes. No statistical differences in mean LCAT values were found between drinkers and nondrinkers. The 5th percentile LCAT value was 4.3 micrograms/ml for both men and women not using hormones. The 95th percentile value was 7.3 micrograms/ml for men and 7.8 micrograms/ml for women regardless of hormone use. Subjects phenotypically LCAT-deficient by clinical criteria and by the absence or near absence of LCAT activity had levels of LCAT mass well below the reference values: 0.73 +/- 0.70, range 0.10 micrograms/ml to 2.65 micrograms/ml, n = 20. Parents or children of LCAT-deficient subjects, i.e., obligate heterozygotes for familial LCAT deficiency, had reduced levels: 3.59 +/- 0.69, range 2.59-4.61 micrograms/ml, n = 19.

摘要

血浆中未酯化胆固醇通过卵磷脂胆固醇酰基转移酶(LCAT)转化为胆固醇酯。采用灵敏的双抗体放射免疫分析法,对太平洋西北地区20 - 59岁成年员工群体的样本进行LCAT血浆水平测定。在调整相对体重差异后,女性的LCAT水平(5.90±1.06,n = 154)显著高于男性(5.49±0.89,n = 83)。在20 - 59岁年龄段,LCAT水平与年龄呈轻微关联:男性r = 0.13,女性r = 0.29。LCAT与相对体重、总胆固醇和低密度脂蛋白胆固醇呈正相关。吸烟男性的LCAT质量显著低于不吸烟男性。饮酒者与不饮酒者的平均LCAT值无统计学差异。未使用激素的男性和女性的LCAT第5百分位数为4.3微克/毫升。无论是否使用激素,男性的第95百分位数为7.3微克/毫升,女性为7.8微克/毫升。根据临床标准以及LCAT活性缺失或几乎缺失而表型为LCAT缺乏的受试者,其LCAT质量水平远低于参考值:0.73±0.70,范围为0.10微克/毫升至2.65微克/毫升,n = 20。LCAT缺乏受试者的父母或子女,即家族性LCAT缺乏的必然杂合子,其水平降低:3.59±0.69,范围为2.59 - 4.61微克/毫升,n = 19。

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