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嗜酸性粒细胞性肺炎的一种新病因:吸食消遣性大麻。

A novel cause of eosinophilic pneumonia: recreational marijuana exposure.

作者信息

Liebling Peter D, Siu Stanton

机构信息

Departments of Internal Medicine, Kaiser Oakland Medical Center, Oakland, CA 94611, USA.

出版信息

J Bronchology Interv Pulmonol. 2013 Apr;20(2):183-5. doi: 10.1097/LBR.0b013e31828caa0d.

DOI:10.1097/LBR.0b013e31828caa0d
PMID:23609259
Abstract

Eosinophilic pneumonia is characterized by pulmonary infiltrates visible on radiography, eosinophilic infiltration into the lung parenchyma, and frequent peripheral eosinophilia. The etiology may be idiopathic or secondary to identifiable causes, including drugs, parasites, toxins, infections, or systemic diseases such as hypereosinophilic syndrome. A 60-year-old man was seen in pulmonary clinic with 4 weeks of cough and wheeze. He was found to have pulmonary infiltrates, a peripheral eosinophilia, and bronchoalveolar lavage demonstrated numerous eosinophils. Careful review of history revealed that the symptoms had started after a recreational exposure to marijuana from a different source than usual. Eosinophilic pneumonia from marijuana has been described once in conjunction with tobacco smoke in the pediatric literature, but to our knowledge this is the first report in the adult literature.

摘要

嗜酸性粒细胞性肺炎的特征是胸部X光片可见肺部浸润、肺实质嗜酸性粒细胞浸润以及外周血嗜酸性粒细胞增多。病因可能是特发性的,也可能继发于可识别的原因,包括药物、寄生虫、毒素、感染或系统性疾病,如高嗜酸性粒细胞综合征。一名60岁男性因咳嗽和喘息4周就诊于肺部门诊。他被发现有肺部浸润、外周血嗜酸性粒细胞增多,支气管肺泡灌洗显示有大量嗜酸性粒细胞。仔细回顾病史发现,症状始于一次与往常不同来源的娱乐性接触大麻之后。小儿文献中曾有过一次将大麻所致嗜酸性粒细胞性肺炎与烟草烟雾联系起来的描述,但据我们所知,这是成人文献中的首例报告。

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1
A novel cause of eosinophilic pneumonia: recreational marijuana exposure.嗜酸性粒细胞性肺炎的一种新病因:吸食消遣性大麻。
J Bronchology Interv Pulmonol. 2013 Apr;20(2):183-5. doi: 10.1097/LBR.0b013e31828caa0d.
2
[The eosinophilic lung].[嗜酸性粒细胞性肺病]
Med Trop (Mars). 1998;58(4 Suppl):447-53.
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[Acute eosinophilic pneumonia induced by cigarette smoking].[吸烟所致急性嗜酸性粒细胞性肺炎]
Nihon Kokyuki Gakkai Zasshi. 2000 Feb;38(2):113-6.
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Pulmonary eosinophilic infiltrates.肺部嗜酸性粒细胞浸润。
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[Pulmonary eosinophilia].[肺嗜酸性粒细胞增多症]
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Eosinophilic pneumonia associated with concomitant cigarette and marijuana smoking.与同时吸烟和吸食大麻相关的嗜酸性粒细胞性肺炎。
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[Case of acute eosinophilic pneumonia possibly caused by an increase in smoking amount].[可能因吸烟量增加导致的急性嗜酸性粒细胞性肺炎病例]
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[Pulmonary infiltrates and peripheral blood eosinophilia].[肺部浸润与外周血嗜酸性粒细胞增多]
Praxis (Bern 1994). 2005 Jan 12;94(1-2):13-6. doi: 10.1024/0369-8394.94.1.13.
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Cureus. 2024 Jul 17;16(7):e64708. doi: 10.7759/cureus.64708. eCollection 2024 Jul.
2
A review of cannabis allergy in the early days of legalization.合法化早期的大麻过敏综述。
Ann Allergy Asthma Immunol. 2023 Mar;130(3):288-295. doi: 10.1016/j.anai.2022.10.016. Epub 2022 Oct 27.
3
Expression and Functions of the CB Receptor in Human Leukocytes.CB受体在人白细胞中的表达及功能
Front Pharmacol. 2022 Feb 22;13:826400. doi: 10.3389/fphar.2022.826400. eCollection 2022.
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Diffuse alveolar haemorrhage in the setting of eosinophilic pneumonia.嗜酸性粒细胞性肺炎背景下的弥漫性肺泡出血
BMJ Case Rep. 2021 Apr 27;14(4):e241672. doi: 10.1136/bcr-2021-241672.
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Vaping Is Not Safe: A Case of Acute Eosinophilic Pneumonia following Cannabis Vapor Inhalation.吸电子烟不安全:一例大麻蒸汽吸入后急性嗜酸性粒细胞性肺炎病例
Case Rep Pulmonol. 2020 Jan 27;2020:9496564. doi: 10.1155/2020/9496564. eCollection 2020.
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Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs.大麻、大麻素和内源性大麻素对肺部的影响。
Front Pharmacol. 2016 Sep 15;7:317. doi: 10.3389/fphar.2016.00317. eCollection 2016.