Image-guided Therapy and Interventional Oncology Unit Department of Radiology Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem, Israel.
Radiology. 2013 May;267(2):321-3. doi: 10.1148/radiol.13130140.
Hamamoto et al (1) were able to demonstrate that combination therapy of a lung tumor by using radiofrequency ablation (RFA) with local injection of an immunostimulant, OK-432, resulted in improved survival when compared with other therapies tested in a VX2 rabbit model. In addition, not only was greater tumor regression seen in a second distant ear tumor implanted prior to the therapy, but also reduced tumor growth was seen when a second tumor implantation (ie, rechallenge) was attempted. These factors strongly suggest the successful activation of systemic antitumor immunity using this approach in this specific tumor model.
滨本等人(1)证明，与在 VX2 兔模型中测试的其他疗法相比，使用射频消融(RFA)联合局部注射免疫刺激剂 OK-432 对肺肿瘤进行联合治疗可提高存活率。此外，不仅在治疗前植入的第二个远隔耳朵肿瘤中观察到更大的肿瘤消退，而且当尝试第二次肿瘤植入(即再挑战)时也观察到肿瘤生长减少。这些因素强烈表明，在这种特定的肿瘤模型中，使用这种方法成功地激活了全身抗肿瘤免疫。
