Midwestern Regional Hospital Limerick /University of Limerick, Limerick, Ireland.
Bone Joint Res. 2012 Apr 1;1(4):50-5. doi: 10.1302/2046-3758.14.2000044. Print 2012 Apr.
The objective of this study was to determine if a synthetic bone substitute would provide results similar to bone from osteoporotic femoral heads during in vitro testing with orthopaedic implants. If the synthetic material could produce results similar to those of the osteoporotic bone, it could reduce or eliminate the need for testing of implants on bone.
Pushout studies were performed with the dynamic hip screw (DHS) and the DHS Blade in both cadaveric femoral heads and artificial bone substitutes in the form of polyurethane foam blocks of different density. The pushout studies were performed as a means of comparing the force displacement curves produced by each implant within each material.
The results demonstrated that test material with a density of 0.16 g/cm(3) (block A) produced qualitatively similar force displacement curves for the DHS and qualitatively and quantitatively similar force displacement curves for the DHS Blade, whereas the test material with a density of 0.08 g/cm(3) (block B) did not produce results that were predictive of those recorded within the osteoporotic cadaveric femoral heads.
This study demonstrates that synthetic material with a density of 0.16 g/cm(3) can provide a good substitute for cadaveric osteoporotic femoral heads in the testing of implants. However we do recognise that no synthetic material can be considered as a definitive substitute for bone, therefore studies performed with artificial bone substrates may need to be validated by further testing with a small bone sample in order to produce conclusive results.
本研究的目的是确定合成骨替代物在与骨科植入物的体外测试中是否能提供类似于骨质疏松性股骨头的结果。如果这种合成材料能够产生与骨质疏松性骨相似的结果，它可能会减少或消除对植入物在骨上进行测试的需求。
使用动力髋螺钉（DHS）和 DHS 刀片在尸体股骨头和不同密度的聚氨酯泡沫块形式的人工骨替代物中进行推出研究。推出研究是作为比较每个植入物在每种材料中产生的力-位移曲线的一种手段进行的。
结果表明，密度为 0.16 g/cm³（块 A）的测试材料为 DHS 产生了定性上相似的力-位移曲线，为 DHS 刀片产生了定性和定量上相似的力-位移曲线，而密度为 0.08 g/cm³（块 B）的测试材料则不能产生可预测骨质疏松性尸体股骨头内记录结果的力-位移曲线。
本研究表明，密度为 0.16 g/cm³的合成材料可以作为骨质疏松性尸体股骨头在植入物测试中的良好替代品。然而，我们确实认识到，没有任何合成材料可以被认为是骨的完全替代品，因此，使用人工骨基质进行的研究可能需要通过进一步用小骨样本进行测试来验证，以产生结论性结果。
