羟基磷灰石涂层会导致骨形成减少：一项在兔子体内的研究。
Coating of titanium with hydroxyapatite leads to decreased bone formation: A study in rabbits.
机构信息
Vestre Viken HF, Ringerike Hospital, Postboks 3024, 3501 Hønefoss, Norway.
出版信息
Bone Joint Res. 2012 Jun 1;1(6):125-30. doi: 10.1302/2046-3758.16.2000050. Print 2012 Jun.
OBJECTIVES
An experimental rabbit model was used to test the null hypothesis, that there is no difference in new bone formation around uncoated titanium discs compared with coated titanium discs when implanted into the muscles of rabbits.
METHODS
A total of three titanium discs with different surface and coating (1, porous coating; 2, porous coating + Bonemaster (Biomet); and 3, porous coating + plasma-sprayed hydroxyapatite) were implanted in 12 female rabbits. Six animals were killed after six weeks and the remaining six were killed after 12 weeks. The implants with surrounding tissues were embedded in methyl methacrylate and grinded sections were stained with Masson-Goldners trichrome and examined by light microscopy of coded sections.
RESULTS
Small amounts of bone were observed scattered along the surface of five of the 12 implants coated with porous titanium, and around one out of 12 porous coated surfaces with Bonemaster. No bone formation could be detected around porous coated implants with plasma-sprayed hydroxyapatite.
CONCLUSION
Porous titanium coating is to some degree osteoinductive in muscles.
目的
本实验通过建立兔模型来验证假设，即未涂层钛盘与涂层钛盘（包括多孔涂层钛盘、多孔涂层钛盘+Bonemaster、多孔涂层钛盘+等离子喷涂羟基磷灰石）在植入兔肌肉后，其周围新骨形成无差异。
方法
将 3 种不同表面和涂层的钛盘（1. 多孔涂层；2. 多孔涂层+Bonemaster；3. 多孔涂层+等离子喷涂羟基磷灰石）植入 12 只雌性兔子中。其中 6 只动物在 6 周后处死，其余 6 只在 12 周后处死。将带有周围组织的植入物用甲基丙烯酸甲酯包埋，磨制切片，用 Masson-Goldners 三色染色，通过编码切片的光学显微镜进行检查。
结果
在 12 个涂层钛盘中有 5 个表面观察到少量的骨散在分布，在 12 个带有 Bonemaster 的多孔涂层表面中有 1 个观察到少量的骨。在带有等离子喷涂羟基磷灰石的多孔涂层钛盘周围未检测到骨形成。
结论
多孔钛涂层在一定程度上具有成骨性。
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