Department of Respiratory Diseases, Tongji Hospital, Key Lab. of Pulmonary Diseases of Health Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gene. 2013 Jul 15;524(1):54-8. doi: 10.1016/j.gene.2013.04.011. Epub 2013 Apr 21.
The role of CCR2-V64I polymorphism in various cancers has been reported in many studies. However, results from published studies on the association between CCR2-V64I polymorphism and cancer risk are conflicting. Therefore, we performed a meta-analysis to estimate the overall cancer risk associated with the polymorphism.
Electronic searches of PubMed and EMBASE were conducted for all publications on the association between this variant and cancer. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association.
Sixteen studies with 2661 cancer patients and 5801 healthy controls were included. Overall, significant association was found between the CCR2-V64I polymorphism and cancer risk (OR=1.84, 95% CI=1.35-2.51, AA vs GA/GG, P=0.37). In the subgroup analysis stratified by cancer types, there was a significant association between this polymorphism and bladder cancer (OR=2.06, 95% CI=1.02-4.15, AA vs GA/GG, P=0.11), cervical cancer (OR=3.34, 95% CI=1.48-7.50, AA vs GG, P=0.56), and oral cancer (OR=2.04, 95% CI=1.46-2.84, GA vs GG, P=0.70). In the subgroup analysis stratified by ethnicities, an increased cancer risk was also found in Europeans (OR=2.31, 95% CI=1.45-3.68, AA vs GA/GG, P=0.16) and Asians (OR=1.88, 95% CI=1.12-3.16, AA vs GA/GG, P=0.92).
This meta-analysis suggested that CCR2-V64I polymorphism may contribute to an increased risk of cancer.
CCR2-V64I 多态性在许多研究中被报道与各种癌症有关。然而，已发表的关于 CCR2-V64I 多态性与癌症风险关联的研究结果存在冲突。因此，我们进行了一项荟萃分析，以评估该多态性与癌症风险之间的总体关联。
对 PubMed 和 EMBASE 进行了电子检索，以获取关于该变异与癌症关联的所有出版物。使用比值比（OR）及其 95%置信区间（95%CI）来评估这种关联的强度。
纳入了 16 项研究，共计 2661 名癌症患者和 5801 名健康对照者。总体而言，CCR2-V64I 多态性与癌症风险之间存在显著关联（OR=1.84，95%CI=1.35-2.51，AA 与 GA/GG，P=0.37）。在按癌症类型分层的亚组分析中，该多态性与膀胱癌（OR=2.06，95%CI=1.02-4.15，AA 与 GA/GG，P=0.11）、宫颈癌（OR=3.34，95%CI=1.48-7.50，AA 与 GG，P=0.56）和口腔癌（OR=2.04，95%CI=1.46-2.84，GA 与 GG，P=0.70）之间存在显著关联。在按种族分层的亚组分析中，也发现欧洲人（OR=2.31，95%CI=1.45-3.68，AA 与 GA/GG，P=0.16）和亚洲人（OR=1.88，95%CI=1.12-3.16，AA 与 GA/GG，P=0.92）的癌症风险增加。
这项荟萃分析表明，CCR2-V64I 多态性可能导致癌症风险增加。
