Wang Lili, Wang Zhiying, Gao Xiuqiu, Li Xin, Sun Xirao, Liu Changfu
Department of Prosthodontics, the Affiliated Hospital of Stomatology and The Second Affiliated Hospital, Liaoning Medical University, Guta District, Jinzhou, 121001, Liaoning Province, China.
Tumour Biol. 2014 Feb;35(2):1149-55. doi: 10.1007/s13277-013-1154-8. Epub 2013 Nov 5.
Data from several case-control studies on the relation between the Cyclin D1 (CCND1) G870A polymorphism and oral cancer susceptibility implicated conflicting conclusions. Thus, a meta-analysis was performed to derive a more precise evaluation of the association. We searched PubMed and Embase for related studies that had been published in English and eight available studies were finally included in the meta-analysis. Odd ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each study. Our meta-analysis suggested that CCND1 G870A polymorphism was not associated with oral cancer risk (OR AA vs. GG = 1.08, 95 % CI = 0.90-1.30, P heterogeneity = 0.175; OR AA + GA vs. GG = 1.02, 95 % CI = 0.91-1.14, P heterogeneity = 0.781; OR AA vs. GA + GG = 1.16, 95 % CI = 0.98-1.36, P heterogeneity = 0.107; OR A vs. G = 1.05 95 % CI = 0.96-1.15, P heterogeneity = 0.211; OR GA vs. GG = 0.94, 95 % CI = 0.82-1.08, P heterogeneity = 0.935). However, in the subgroup analysis by ethnicity, possible significance among Asian groups was indicated in two genetic models (OR AA vs. GA + GG = 1.27, 95 % CI = 1.05-1.54, P heterogeneity = 0.572; OR allele A vs. allele G = 1.11, 95 % CI = 1.00-1.24, P heterogeneity = 0.211). Taken together, the meta-analysis revealed that CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians.
多项关于细胞周期蛋白D1（CCND1）G870A多态性与口腔癌易感性之间关系的病例对照研究得出了相互矛盾的结论。因此，进行了一项荟萃分析以获得更精确的关联评估。我们在PubMed和Embase中检索了以英文发表的相关研究，最终有八项可用研究被纳入荟萃分析。计算每项研究的比值比（OR）和95%置信区间（CI）。我们的荟萃分析表明，CCND1 G870A多态性与口腔癌风险无关（OR AA vs. GG = 1.08，95%CI = 0.90 - 1.30，P异质性 = 0.175；OR AA + GA vs. GG = 1.02，95%CI = 0.91 - 1.14，P异质性 = 0.781；OR AA vs. GA + GG = 1.16，95%CI = 0.98 - 1.36，P异质性 = 0.107；OR A vs. G = 1.05，95%CI = 0.96 - 1.15，P异质性 = 0.211；OR GA vs. GG = 0.94，95%CI = 0.82 - 1.08，P异质性 = 0.935）。然而，在按种族进行的亚组分析中，在两个遗传模型中显示亚洲人群中可能存在显著意义（OR AA vs. GA + GG = 1.27，95%CI = 1.05 - 1.54，P异质性 = 0.572；OR等位基因A vs.等位基因G = 1.11，95%CI = 1.00 - 1.24，P异质性 = 0.211）。综上所述，荟萃分析表明CCND1 G870A多态性可能与亚洲人患口腔癌的易感性相关。
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