Santos Erinaldo Ubirajara Damasceno dos, Lima Géssica Dayane Cordeiro de, Oliveira Micheline de Lucena, Heráclio Sandra de Andrade, Silva Hildson Dornelas Angelo da, Crovella Sergio, Maia Maria de Mascena Diniz, Souza Paulo Roberto Eleutério de
Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
Universidade de Pernambuco, Recife, PE, Brasil.
Mem Inst Oswaldo Cruz. 2016 Mar;111(3):174-80. doi: 10.1590/0074-02760150367. Epub 2016 Mar 15.
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.
趋化因子受体的多态性在宫颈上皮内瘤变（CIN）进展为宫颈癌（CC）的过程中起重要作用。我们的研究检测了巴西人群中CCR2 - 64I（rs1799864）和CCR5 - Δ32（rs333）多态性与发生宫颈病变（CIN和CC）易感性之间的关联。采用聚合酶链反应 - 限制性片段长度多态性方法，对139例宫颈病变女性和151例无宫颈病变女性进行CCR2 - 64I和CCR5 - Δ32多态性基因分型。携带CCR2 - 64I多态性杂合或纯合基因型（GA + AA）的个体似乎发生宫颈病变的风险较低[比值比（OR）= 0.37，p = 0.0008]。A等位基因情况相同（OR = 0.39，p = 0.0002），而未检测到与CCR5 - Δ32多态性的关联（p > 0.05）。关于人乳头瘤病毒（HPV）类型，携带CCR2 - 64I多态性的患者对16型HPV感染有保护作用（OR = 0.35，p = 0.0184）。总之，我们的研究表明CCR2 - 64I rs1799864多态性对宫颈病变（CIN和CC）的发生以及HPV 16感染的易感性具有保护作用。
