Campos Raquel M S, de Mello Marco Túlio, Tock Lian, da Silva Patrícia Leão, Corgosinho Flávia C, Carnier June, de Piano Aline, Sanches Priscila L, Masquio Deborah C L, Tufik Sergio, Dâmaso Ana R
J Pediatr Endocrinol Metab. 2013;26(7-8):663-8. doi: 10.1515/jpem-2012-0336.
Obesity is a chronic inflammatory condition with numerous metabolic consequences to the organism, highlighting its influence on bone mass. Therefore, the aim of this study was to verify the role of visceral fat, leptin, adiponectin and ghrelin on bone mineral density in obese post-puberty adolescents girls, submitted to an interdisciplinary therapy. The study involved 20 post-puberty obese adolescent girls: 16±1.5 years of age, 98.9±15.8 kg (weight), 1.60±0.72 m (height) and 37.2±4.8 kg/m2 [body mass index (BMI)]. Anthropometric measurements, body composition, visceral fat, subcutaneous fat, bone mineral density and content were determined. Ghrelin, leptin and adiponectin were analyzed and the leptin/adiponectin ratio was calculated. Our findings showed a significant increase in adiponectin concentration and a reduction in body weight, BMI, total fat mass, visceral and subcutaneous fat. In addition, ghrelin (r2=-0.53; p=0.02) visceral fat (r2=-0.46, p=0.04) (r2 -0.66, p=0.001) and leptin/adiponectin ratio (r2 -0.56, p=0.01) were negative predictors for bone mineral density and content in obese adolescent girls, respectively. It provides a novel physiologically concept that may shed light on the etiology of osteoporosis and help to identify new therapeutic targets. However this should be confirmed in a large cohort study.
肥胖是一种慢性炎症性疾病，会给机体带来众多代谢后果，凸显了其对骨量的影响。因此，本研究的目的是验证内脏脂肪、瘦素、脂联素和胃饥饿素在接受跨学科治疗的青春期后肥胖少女骨矿物质密度中的作用。该研究纳入了20名青春期后肥胖少女：年龄16±1.5岁，体重98.9±15.8千克，身高1.60±0.72米，体重指数（BMI）为37.2±4.8千克/平方米。测定了人体测量学指标、身体成分、内脏脂肪、皮下脂肪、骨矿物质密度和含量。分析了胃饥饿素、瘦素和脂联素，并计算了瘦素/脂联素比值。我们的研究结果显示脂联素浓度显著升高，体重、BMI、总脂肪量、内脏和皮下脂肪减少。此外，胃饥饿素（r2=-0.53；p=0.02）、内脏脂肪（r2=-0.46，p=0.04）（r2 -0.66，p=0.001）和瘦素/脂联素比值（r2 -0.56，p=0.01）分别是肥胖少女骨矿物质密度和含量的负预测因子。这提供了一个新的生理学概念，可能有助于揭示骨质疏松症的病因，并有助于确定新疗法靶点。然而，这一点应在大型队列研究中得到证实。
