Chaplais Elodie, Naughton Geraldine, Greene David, Dutheil Frederic, Pereira Bruno, Thivel David, Courteix Daniel
Laboratory of the Metabolic Adaptations to Exercise Under Physiological and Pathological Conditions (AME2P), EA 3533, Blaise Pascal University, 5 Impasse Amelie Murat, TS60026 cs 60026, Aubière Cedex, 63178, Clermont-Ferrand, France.
School of Exercise Science, Australian Catholic University, Strathfield Campus, Locked Bag 2002, Strathfield, NSW, 2135, Australia.
J Bone Miner Metab. 2018 Jan;36(1):12-30. doi: 10.1007/s00774-017-0858-z. Epub 2017 Aug 4.
Given the rise in pediatric obesity, clarifications on the relationship between obesity and bone health and on the impact of structured intervention on this relationship are needed. This systematic review and meta-analysis investigated the effect of obesity on bone health and assessed the effect of structured intervention in children and adolescents with obesity. Medline complete, OVID, CINAHL, EMBASE and PubMed databases were searched for studies on obesity and bone health variables up to September 2016, then an update occurred in March 2016. Search items included obesity, childhood, dual energy X-ray absorptiometry and peripheral quantitative computed tomography. Twenty-three studies (14 cross-sectional and nine longitudinal) matched the inclusion criteria. Results from the meta-analysis (cross-sectional studies) confirmed that children and adolescents with obesity have higher bone content and density than their normal weight peers. Results from longitudinal studies remain inconclusive as only 50% of the included studies reported a positive effect of a structured intervention program on bone health. As such, the meta-analysis reported that structured intervention did not influence bone markers despite having beneficial effects on general health in youth with obesity.
鉴于儿童肥胖率的上升，有必要澄清肥胖与骨骼健康之间的关系以及结构化干预对这种关系的影响。本系统评价和荟萃分析研究了肥胖对骨骼健康的影响，并评估了针对肥胖儿童和青少年的结构化干预的效果。检索了Medline complete、OVID、CINAHL、EMBASE和PubMed数据库，以查找截至2016年9月关于肥胖与骨骼健康变量的研究，然后在2016年3月进行了更新。检索词包括肥胖、儿童期、双能X线吸收法和外周定量计算机断层扫描。23项研究（14项横断面研究和9项纵向研究）符合纳入标准。荟萃分析（横断面研究）的结果证实，肥胖儿童和青少年的骨量和骨密度高于正常体重的同龄人。纵向研究的结果尚无定论，因为只有50%的纳入研究报告了结构化干预计划对骨骼健康有积极影响。因此，荟萃分析报告称，结构化干预尽管对肥胖青少年的总体健康有有益影响，但并未影响骨标志物。
