Chaplais Elodie, Thivel David, Greene David, Dutheil Frederic, Duche Pascale, Naughton Geraldine, Courteix Daniel
Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont University, Blaise Pascal University, Clermont-Ferrand, France.
School of Exercise Science, Australian Catholic University, Strathfield campus, Locked Bag 2002, Strathfield, NSW, 2135, Australia.
J Bone Miner Metab. 2015 Nov;33(6):592-602. doi: 10.1007/s00774-015-0654-6. Epub 2015 Mar 22.
The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body's responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.
儿童超重和肥胖患病率的不断上升已成为全球主要关注的问题。本综述的目的是证明肥胖儿童和青少年脂肪组织释放的产物与骨组织激素生成之间的潜在相互作用。深入了解脂肪细胞和骨细胞活动之间的复杂相互作用，可能有助于从机制上理解青春期身体对体重减轻的反应。这些知识还可能揭示这些干预措施所遇到的任何副作用。目前，骨-脂肪相互作用的概念尚未完全阐明，其机制仍存在争议。了解脂肪组织释放的产物与骨组织产生的激素之间的局部相互作用需要进一步研究。
