Division in Anatomy and Developmental Biology, Department of Oral Biology, Brain Korea 21 project, Oral Science Research Institute, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul, Korea.
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):139-42. doi: 10.1007/s10911-013-9278-4. Epub 2013 Apr 24.
The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.
乳腺是外胚层的附属物，也是哺乳动物的一个特征。由于它是最近进化而来的新事物，许多对于各种脊椎动物器官的个体发生和形态发生至关重要的分子，包括成纤维细胞生长因子（FGF）信号通路中的分子，都被用于乳腺的诱导、维持和形态发生。了解 FGF 信号如何调节正常乳腺发育过程中基本细胞行为的机制，可能有助于确定其在乳腺癌进展过程中失调的后果。
