Division of Breast Cancer Research, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):149-54. doi: 10.1007/s10911-013-9286-4. Epub 2013 May 7.
We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.
我们回顾了神经调节蛋白 3（Nrg3）和 ErbB 受体信号在胚胎乳腺发育中的作用。神经调节蛋白是一种生长因子，可与其同源 ErbB 受体酪氨酸激酶结合并激活，该受体酪氨酸激酶与乳腺发育和乳腺癌的发生有明确的作用。研究表明，Nrg3 的表达对胚胎乳腺发育的早期阶段有深远的影响。网络分析表明，Nrg/ErbB 信号如何与胚胎乳腺发育的其他主要调节因子整合，引发乳腺谱系建立时发生的形态发生过程和细胞命运决定。
