Laboratoire de Neurosciences, EA481, Université de Franche-Comté, (Emeritus), 25030, Besançon Cedex, France.
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):93-104. doi: 10.1007/s10911-013-9298-0. Epub 2013 Jun 5.
Our understanding of prenatal morphogenesis of mammary glands has recently greatly advanced. This review focuses on morphogenesis proper, as well as cellular processes and tissue interactions involved in the progression of the embryonic mammary gland through sequential morphogenic stages in both the mouse and rabbit embryo. We provide a synthesis of both historical and more recent studies of embryonic mammary gland development, as well as arguments to revise old concepts about mechanisms of mammary line and rudiment formation. Finally, we highlight outstanding issues that remain to be addressed.
我们对乳腺先天发生的理解最近有了很大的进展。这篇综述的重点是形态发生本身，以及涉及胚胎乳腺通过在小鼠和兔胚胎中的连续形态发生阶段的细胞过程和组织相互作用。我们对胚胎乳腺发育的历史和更近期的研究进行了综合，并提出了修正关于乳腺线和原基形成机制的旧概念的论据。最后，我们强调了仍有待解决的突出问题。
