验证新加坡血液透析患者使用肾脏病生存质量量表（KDQOL-36）英文版的情况。
Validation of the English version of the Kidney Disease Quality of Life questionnaire (KDQOL-36) in haemodialysis patients in Singapore.
机构信息
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
出版信息
Patient. 2013;6(2):135-41. doi: 10.1007/s40271-013-0015-2.
BACKGROUND
To validate a widely used health outcomes instrument for patients with chronic kidney disease and on dialysis, the Kidney Disease Quality of Life questionnaire (KDQOL-36), in English-speaking haemodialysis patients in Singapore.
METHODS
This study is a secondary data analysis using the KDQOL-SF (version 1.3) data collected from a cross-sectional survey of haemodialysis patients in Singapore. Cronbach's α was used to test internal consistency reliability. Multi-item scales were assessed using item-to-scale correlation and factor analysis. Both confirmatory and exploratory factor analyses were performed separately for generic and disease-targeted scales. Construct validity was assessed by correlation between disease-targeted and generic scales. Criterion validity was assessed by correlation of the physical component summary (PCS-12) and mental component summary (MCS-12) from KDQOL-36 with the corresponding PCS-36 and MCS-36 from the KDQOL-SF.
RESULTS
Three hundred ninety-four patients who completed the interviews in English [male 55.8 %, mean age (SD) 52.4 (11.7) years] were involved. Kidney disease scales exhibited desirable internal consistency (Cronbach's α 0.822-0.906) and item-to-scale correlation (range 0.763-0.903), and a three-factor model fit the data well [comparative fit index (CFI) 0.934, root mean square error of approximation (RMSEA) 0.085]. For the generic Short Form 12 Health Survey (SF-12) items, a two-factor model (physical and mental) showed poor overall fit, but a three-factor structure (role, physical and mental functions) achieved good model fit (CFI 0.999, RMSEA 0.027). Correlation between disease-targeted and generic scales was weak to moderate (range 0.286-0.418). Correlation between SF-12 and SF-36 was 0.750 for PCS and 0.797 for MCS.
CONCLUSION
The English version of the KDQOL-36 appears to be reliable and valid to measure quality of life for haemodialysis patients in Singapore.
背景
为了验证一种在英语国家广泛使用的针对慢性肾脏病和透析患者的健康结果评估工具，即肾脏病生活质量问卷（KDQOL-36），我们在新加坡的血液透析患者中进行了一项横断面调查。
方法
本研究是对新加坡血液透析患者的横断面调查中收集的 KDQOL-SF（版本 1.3）数据进行的二次数据分析。使用克朗巴赫 α 检验来检验内部一致性信度。多项目量表通过项目与量表的相关性和因子分析进行评估。分别对通用量表和疾病靶向量表进行验证性和探索性因子分析。通过疾病靶向量表和通用量表之间的相关性来评估结构有效性。通过 KDQOL-36 的生理成分综合得分（PCS-12）和心理成分综合得分（MCS-12）与 KDQOL-SF 的相应 PCS-36 和 MCS-36 的相关性来评估效标效度。
结果
共有 394 名接受英语访谈的患者参与了本研究（男性占 55.8%，平均年龄为 52.4±11.7 岁）。肾脏疾病量表表现出良好的内部一致性（克朗巴赫 α 为 0.822-0.906）和项目与量表的相关性（范围为 0.763-0.903），三因子模型能很好地拟合数据（比较拟合指数为 0.934，近似均方根误差为 0.085）。对于通用的 12 项简短健康调查（SF-12）项目，两因子模型（生理和心理）的整体拟合效果较差，但三因子结构（角色、生理和心理功能）的拟合效果较好（比较拟合指数为 0.999，近似均方根误差为 0.027）。疾病靶向量表和通用量表之间的相关性较弱至中度（范围为 0.286-0.418）。SF-12 和 SF-36 之间的相关性为 PCS 为 0.750，MCS 为 0.797。
结论
KDQOL-36 的英文版在新加坡血液透析患者中似乎是可靠和有效的，可用于测量生活质量。
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