Department of Gastroenterology, the First Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
World J Gastroenterol. 2013 Apr 21;19(15):2419-24. doi: 10.3748/wjg.v19.i15.2419.
To determine the effects of gastric juice on the development of esophageal adenocarcinoma (EAC).
A animal model of duodenogastroesophageal reflux was established in Sprague-Dawley rats undergoing esophagoduodenostomy. The development of EAC and forestomach adenocarcinoma was investigated 40 wk after the treatment. Intraluminal pH and bile of the forestomach were measured.
There were no significant differences in pH (t = 0.117, P = 0.925) or bile (χ² = 0.036, P = 0.85) in the forestomach before and 40 wk after esophagoduodenostomy. There were also no significant differences between the model and controls during esophagoduodenostomy or 40 wk after esophagoduodenostomy. The incidence of intestinal metaplasia (88%) and intestinal metaplasia with dysplasia and adenocarcinoma (28%) in the esophagus in the model was higher than in the controls 40 wk after surgery (χ² = 43.06, P < 0.001 and χ² = 9.33, P = 0.002, respectively) and in the forestomach in the model (χ² = 32.05, P < 0.001 and χ² = 8.14, P = 0.004, respectively). The incidence rates of inflammation in the esophagus and forestomach were 100% and 96%, respectively (χ² = 1.02, P = 0.31) in the model, which was higher than in the esophageal control (6.8%) (χ² = 42.70, P < 0.001).
Gastric juice exposure may not cause intestinal metaplasia with dysplasia or adenocarcinoma of the forestomach and may not be related to EAC.
确定胃酸对食管腺癌（EAC）发展的影响。
对行食管胃吻合术的 Sprague-Dawley 大鼠建立十二指肠胃食管反流动物模型。治疗 40 周后，研究 EAC 和胃前腺癌的发展情况。测量胃前腔的腔内 pH 值和胆汁。
食管胃吻合术前和术后 40 周，胃前腔的 pH 值（t = 0.117，P = 0.925）或胆汁（χ² = 0.036，P = 0.85）均无显著差异。在食管胃吻合术期间或吻合术后 40 周，模型组与对照组之间也无显著差异。模型组食管的肠上皮化生（88%）和肠上皮化生伴异型增生和腺癌（28%）的发生率高于术后 40 周的对照组（χ² = 43.06，P < 0.001 和 χ² = 9.33，P = 0.002），也高于模型组胃前腔（χ² = 32.05，P < 0.001 和 χ² = 8.14，P = 0.004）。模型组食管和胃前腔的炎症发生率分别为 100%和 96%（χ² = 1.02，P = 0.31），高于食管对照组（6.8%）（χ² = 42.70，P < 0.001）。
胃酸暴露可能不会导致胃前腔的异型增生或腺癌，也可能与 EAC 无关。
